Recent advances in the formulation of PLGA microparticles for controlled drug delivery
Polymeric microparticles (MPs) are recognized as very popular carriers to increase the
bioavailability and bio-distribution of both lipophilic and hydrophilic drugs. Among different …
bioavailability and bio-distribution of both lipophilic and hydrophilic drugs. Among different …
Recent development in nanoencapsulation and delivery of natural bioactives through chitosan scaffolds for various biological applications
Nowadays, nano/micro-encapsulation as a pioneering technique may significantly improve
the bioavailability and durability of Natural bioactives. For this purpose, chitosan as a …
the bioavailability and durability of Natural bioactives. For this purpose, chitosan as a …
An inhalable hybrid biomimetic nanoplatform for sequential drug release and remodeling lung immune homeostasis in acute lung injury treatment
Interactions of lung macrophages and recruited neutrophils with the lung microenvironment
continuously aggravate the dysregulation of lung inflammation in the pathogenesis of acute …
continuously aggravate the dysregulation of lung inflammation in the pathogenesis of acute …
Improving the efficacy of inhaled drugs in cystic fibrosis: Challenges and emerging drug delivery strategies
I d'Angelo, C Conte, MI La Rotonda, A Miro… - Advanced drug delivery …, 2014 - Elsevier
Cystic fibrosis (CF) is the most common autosomal recessive disease in Caucasians
associated with early death. Although the faulty gene is expressed in epithelia throughout …
associated with early death. Although the faulty gene is expressed in epithelia throughout …
Nanomedicine approaches for the pulmonary treatment of cystic fibrosis
Cystic fibrosis (CF) is a genetic disease affecting today nearly 70,000 patients worldwide
and characterized by a hypersecretion of thick mucus difficult to clear arising from the …
and characterized by a hypersecretion of thick mucus difficult to clear arising from the …
Enhanced eradication of bacterial biofilms with DNase I-loaded silver-doped mesoporous silica nanoparticles
Deoxyribonuclease I (DNase I) was successfully loaded and delivered by silver-doped
mesoporous silica nanoparticles (MSN-Ag) for biofilm treatments. This nanoformulation …
mesoporous silica nanoparticles (MSN-Ag) for biofilm treatments. This nanoformulation …
Inhalable lactoferrin–chondroitin nanocomposites for combined delivery of doxorubicin and ellagic acid to lung carcinoma
Aim: The use of inhalable nanomedicines can overcome the Enhanced permeation and
retention effect (EPR)-associated drawbacks in lung cancer therapy via systemic …
retention effect (EPR)-associated drawbacks in lung cancer therapy via systemic …
Developing inhaled protein therapeutics for lung diseases
Biologic therapeutics such as protein/polypeptide drugs are conventionally administered
systemically via intravenous injection for the treatment of diseases including lung diseases …
systemically via intravenous injection for the treatment of diseases including lung diseases …
Targeting sialic acid residues on lung cancer cells by inhalable boronic acid-decorated albumin nanocomposites for combined chemo/herbal therapy
MM Elgohary, MW Helmy, EZA Abdelfattah… - Journal of Controlled …, 2018 - Elsevier
Etoposide (ETP), as a potential treatment for lung cancer, has limited application due to its
poor solubility, and systemic side effects. In the current study, we propose inhalable …
poor solubility, and systemic side effects. In the current study, we propose inhalable …
Rifampicin-carbohydrate spray-dried nanocomposite: a futuristic multiparticulate platform for pulmonary delivery
MM Mehanna, SM Mohyeldin… - International journal of …, 2019 - Taylor & Francis
Purpose Rifampicin, a first-line anti-tuberculosis drug, was loaded into a carbohydrate-
based spray-dried nanocomposite with the aim to design a dry powder inhalation …
based spray-dried nanocomposite with the aim to design a dry powder inhalation …