[HTML][HTML] The molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives

S Wang, Y Zheng, F Yang, L Zhu, XQ Zhu… - Signal transduction and …, 2021 - nature.com
Pancreatic cancer is an increasingly common cause of cancer mortality with a tight
correspondence between disease mortality and incidence. Furthermore, it is usually …

[HTML][HTML] Mechanisms of obesity-and diabetes mellitus-related pancreatic carcinogenesis: a comprehensive and systematic review

R Ruze, J Song, X Yin, Y Chen, R Xu… - Signal transduction and …, 2023 - nature.com
Research on obesity-and diabetes mellitus (DM)-related carcinogenesis has expanded
exponentially since these two diseases were recognized as important risk factors for …

[HTML][HTML] Prognostic value of immune factors in the tumor microenvironment of patients with pancreatic ductal adenocarcinoma

S Kiryu, Z Ito, M Suka, T Bito, S Kan, K Uchiyama… - BMC cancer, 2021 - Springer
Background Both activated tumor-infiltrating lymphocytes (TILs) and immune-suppressive
cells, such as regulatory T cells (Tregs), in the tumor microenvironment (TME) play an …

[HTML][HTML] A multimodal imaging workflow for monitoring CAR T cell therapy against solid tumor from whole-body to single-cell level

R Pfeifer, J Henze, K Wittich, A Gosselink… - Theranostics, 2022 - ncbi.nlm.nih.gov
CAR T cell research in solid tumors often lacks spatiotemporal information and therefore,
there is a need for a molecular tomography to facilitate high-throughput preclinical …

[HTML][HTML] The tumor–stroma ratio and the immune microenvironment improve the prognostic prediction of pancreatic ductal adenocarcinoma

M Lu, Y Zou, P Fu, Y Li, P Wang, G Li, S Luo, Y Chen… - Discover Oncology, 2023 - Springer
Tumor-infiltrating immune cells and fibroblasts are significant components of the tumor
microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC), and they participate …

Chemoresistance in pancreatic ductal adenocarcinoma: Overcoming resistance to therapy

P Bhoopathi, P Mannangatti, SK Das, PB Fisher… - Advances in Cancer …, 2023 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC), a prominent cause of cancer deaths worldwide,
is a highly aggressive cancer most frequently detected at an advanced stage that limits …

Organoids at the PUB: the porcine urinary bladder serves as a pancreatic niche for advanced cancer modeling

MK Melzer, M Breunig, F Arnold… - Advanced …, 2022 - Wiley Online Library
Despite intensive research and progress in personalized medicine, pancreatic ductal
adenocarcinoma remains one of the deadliest cancer entities. Pancreatic duct‐like …

[HTML][HTML] Circulating monocytes serve as novel prognostic biomarker in pancreatic ductal adenocarcinoma patients

FJ Hansen, P David, M Akram, S Knoedler… - Cancers, 2023 - mdpi.com
Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal
malignant diseases. The association of monocytes with worse outcomes has been …

RINT1 regulates SUMOylation and the DNA damage response to preserve cellular homeostasis in pancreatic cancer

F Arnold, J Gout, H Wiese, SE Weissinger, E Roger… - Cancer Research, 2021 - AACR
Pancreatic ductal adenocarcinoma (PDAC) still presents with a dismal prognosis despite
intense research. Better understanding of cellular homeostasis could identify druggable …

[HTML][HTML] Association between AHR Expression and Immune Dysregulation in Pancreatic Ductal Adenocarcinoma: Insights from Comprehensive Immune Profiling of …

A Bartkeviciene, A Jasukaitiene, I Zievyte, D Stukas… - Cancers, 2023 - mdpi.com
Simple Summary This study investigated the role of aryl hydrocarbon receptor (AHR)
expression in pancreatic ductal adenocarcinoma patients' peripheral blood immune cells …