Eosinophils are a minority circulating granulocyte classically viewed as being involved in
host defense against parasites and promoting allergic reactions. However, a series of new …

Notch proteins regulate a broad spectrum of cell fate decisions and differentiation processes
during fetal and postnatal development. Mammals have four Notch receptors that bind five …

OBJECTIVE: The Hox gene family of transcription factors is thought to be involved in the
regulation of primitive hematopoietic cells, including stem cells and early committed …

Neural stem cells (NSCs) in vitro are able to generate clonal structures,“neurospheres,” that
exhibit intra-clonal neural cell-lineage diversity; ie, they contain, in addition to NSCs …

Notch signaling coordinates numerous cellular processes and has been implicated in many
pathological conditions, including rheumatoid arthritis (RA). Although the role of Notch …

Notch signaling is a well‐conserved pathway involved in cell fate decisions, proliferation
and apoptosis. We report on the involvement of Notch signaling in regulating gene …

The discovery that Notch, a key regulator of cell fate determination, is functional in the
vasculature has greatly improved our understanding of differentiation and specialization of …

Notch proteins are used repeatedly to direct developmental cell fate decisions in multiple
organs. During hematopoiesis and immune development, Notch is critical for T/B lineage …

Mammalian genomes encode up to four Notch receptors (Notch1–4) and five Notch ligands
of the DSL (Delta/Serrate/Lag-2) family, and Notch signaling controls a wide spectrum of …

Notch is a critical regulator of angiogenesis, vascular differentiation, and vascular integrity.
We investigated whether Notch signaling affects macrophage function during retinal …