Critical features of human addiction are increasingly being incorporated into complementary
animal models, including escalation of drug intake, punished drug seeking and taking …

Substance-use disorders are a global public health problem that arises from behavioral
misallocation between drug use and more adaptive behaviors maintained by nondrug …

Background Treatment of stimulant-use disorders remains a formidable challenge, and the
dopamine transporter (DAT) remains a potential target for antagonist or agonist-like …

Cocaine use disorder is a persistent public health problem for which no widely effective
medications exist. Self-administration procedures, which have shown good predictive …

Cocaine addiction is a persistent and insidious public health problem (Pomara et al, 2012).
Despite evidence for sustained prevalence, clinical harm, and demand for treatment, the …

Individuals with cocaine use disorder chronically self-administer cocaine to the detriment of
other rewarding activities, a phenomenon best modeled in laboratory drug-choice …

Drug self-administration procedures are the gold standard for laboratory research to study
mechanisms of drug use disorders and evaluate candidate medications. However …

The acute and chronic effects of abused psychostimulants on monoamine transporters and
associated neurobiology have encouraged development of candidate medications that …

Cocaine use disorder is a global public health problem for which there are no Food and
Drug Administration-approved pharmacotherapies. Emerging preclinical evidence has …

Opinion statement Drug addiction is a disease that manifests as an inappropriate allocation
of behavior towards the procurement and use of the abused substance and away from other …