The injured spinal cord is difficult to repair and regenerate. Traditional treatments are not
effective. Stem cells are a type of cells that have the potential to differentiate into various …

Introduction: Spinal cord injury (SCI) is a devastating condition, where regenerative failure
and cell loss lead to paralysis. The heterogeneous and time-sensitive pathophysiology has …

Somatic cell reprogramming to a pluripotent state continues to challenge many of our
assumptions about cellular specification, and despite major efforts, we lack a complete …

Pluripotency is defined by the ability of a cell to differentiate to the derivatives of all the three
embryonic germ layers: ectoderm, mesoderm and endoderm. Pluripotent cells can be …

The rigorous characterization of distinct induced pluripotent stem cells (iPSC) derived from
multiple reprogramming technologies, somatic sources, and donors is required to …

Clinical applications of induced pluripotent stem cells (iPSCs) require development of
technologies for the production of “footprint-free”(gene integration-free) iPSCs, which avoid …

Differentiated cells can be converted into pluripotent stem cells by expressing the
transcription factors OCT4, SOX2, KLF4, and MYC (OSKM) in a process known as …

As a group, we met to discuss the current challenges for creating meaningful patient-specific
in vitro models to study brain disorders. Although the convergence of findings between …

In vitro and in vivo studies reported the anti-cancer potential of organosulfur compounds
(OSCs) as they trigger biological effects leading to cell cycle arrest with accumulation of cells …

Since the discovery of microRNAs (miRNAs) in the early 1990s, these small molecules have
been increasingly recognized as key players in the regulation of critical biological …