The rapid resistance of pathogens to antibiotics has emerged as a major threat to global
health. Identification of new antibiotic targets is thus needed for developing alternative …

Riboswitches are 5′ RNA regulatory elements that are capable of binding to various
ligands, such as small metabolites, ions and tRNAs, leading to conformational changes and …

Using supramolecules for protein function regulation is an effective strategy in chemical
biology and drug discovery. However, due to the presence of multiple binding sites on …