[HTML][HTML] A comprehensive review of cholinesterase modeling and simulation
D De Boer, N Nguyen, J Mao, J Moore, EJ Sorin - Biomolecules, 2021 - mdpi.com
The present article reviews published efforts to study acetylcholinesterase and
butyrylcholinesterase structure and function using computer-based modeling and simulation …
butyrylcholinesterase structure and function using computer-based modeling and simulation …
Recent advancements in chromone as a privileged scaffold towards the development of small molecules for neurodegenerative therapeutics
Neurodegenerative disorders, ie, Alzheimer's or Parkinson's disease, involve progressive
degeneration of the central nervous system, resulting in memory loss and cognitive …
degeneration of the central nervous system, resulting in memory loss and cognitive …
In-vitro evaluation of antioxidant and anticholinesterase activities of novel pyridine, quinoxaline and s-triazine derivatives
Cholinesterase enzymes such as acetylcholinesterase (AChE) and butyrylcholinesterase
(BuChE) cause hydrolysis of acetylcholine (ACh), a neurotransmitter responsible for the …
(BuChE) cause hydrolysis of acetylcholine (ACh), a neurotransmitter responsible for the …
Biological activities of [1,2,4]triazolo[1,5-a]pyrimidines and analogs
S Pinheiro, EMC Pinheiro, EMF Muri… - Medicinal Chemistry …, 2020 - Springer
Abstract The [1, 2, 4] triazolo [1, 5-a] pyrimidines (TPs) comprise an important class of non-
naturally occurring small molecules that aroused the interest of researches. This scaffold is …
naturally occurring small molecules that aroused the interest of researches. This scaffold is …
A cascade synthesis, in vitro cholinesterases inhibitory activity and docking studies of novel Tacrine-pyranopyrazole derivatives
C Derabli, I Boualia, AB Abdelwahab… - Bioorganic & medicinal …, 2018 - Elsevier
In this work, we describe the preparation of some new Tacrine analogues modified with a
pyranopyrazole moiety. A one-pot multicomponent reaction of 3-methyl-1 H-pyrazol-5 (4H) …
pyranopyrazole moiety. A one-pot multicomponent reaction of 3-methyl-1 H-pyrazol-5 (4H) …
Design, synthesis, biological activity evaluation and in silico studies of new nicotinohydrazide derivatives as multi-targeted inhibitors for Alzheimer's disease
A new series of 6‑chloro-N'-(substituted benzylidene) nicotinohydrazide were synthesized
via condensation reactions between the corresponding hydrazides and aldehydes. All …
via condensation reactions between the corresponding hydrazides and aldehydes. All …
An exhaustive compilation on chemistry of triazolopyrimidine: A journey through decades
The triazolopyrimidine scaffold represents one of the privileged structure in chemistry, and
there has been an increase in number of studies utilizing this scaffold and its derivatives …
there has been an increase in number of studies utilizing this scaffold and its derivatives …
Design and development of novel N-(pyrimidin-2-yl)-1, 3, 4-oxadiazole hybrids to treat cognitive dysfunctions
Novel hybrids bearing a 2-aminopyrimidine (2-AP) moiety linked to substituted 1, 3, 4-
oxadiazoles were designed, synthesized and biologically evaluated. Among the developed …
oxadiazoles were designed, synthesized and biologically evaluated. Among the developed …
[HTML][HTML] Pyrimidine analogues for the management of neurodegenerative diseases
S Pant, A Kapri, S Nain - European Journal of Medicinal Chemistry Reports, 2022 - Elsevier
Neurodegenerative diseases are one of the leading causes of mortality worldwide. Currently
available therapeutic agents provide symptomatic relief to a great level. Still, there is a need …
available therapeutic agents provide symptomatic relief to a great level. Still, there is a need …
Quinoline carboxamide core moiety-based compounds inhibit P. falciparum falcipain-2: Design, synthesis and antimalarial efficacy studies
Abstract Targeting Falcipain-2 (FP2) for the development of antimalarials is a promising and
established concept in antimalarial drug discovery and development. FP2, a member of …
established concept in antimalarial drug discovery and development. FP2, a member of …