Diabetic sensorimotor peripheral neuropathy (DSPN) is a serious complication of diabetes
mellitus and is associated with increased mortality, lower-limb amputations and distressing …

Neuropathic pain is a frequent condition caused by a lesion or disease of the central or
peripheral somatosensory nervous system. A frequent cause of peripheral neuropathic pain …

Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs.
Our understanding of the genesis of this injury and of potential interventions to prevent, limit …

Diabetic neuropathy is regarded as one of the most debilitating outcomes of diabetes
mellitus and may cause pain, decreased motility, and even amputation. Diabetic neuropathy …

Importance Familial amyloid polyneuropathy, a lethal genetic disease caused by
aggregation of variant transthyretin, induces progressive peripheral nerve deficits and …

Diabetic neuropathies (DNs) differ in clinical course, distribution, fiber involvement (type and
size), and pathophysiology, the most typical type being a length-dependent distal symmetric …

Diabetic polyneuropathy (DPN) is defined as peripheral nerve dysfunction. There are three
main alterations involved in the pathologic changes of DPN: inflammation, oxidative stress …

Objective To develop a scientifically sound and clinically relevant evidence-based guideline
for the treatment of painful diabetic neuropathy (PDN). Methods We performed a systematic …

Diabetic neuropathy is one of the clinical syndromes characterized by pain and substantial
morbidity primarily due to a lesion of the somatosensory nervous system. The burden of …

The global epidemic of prediabetes and diabetes has led to a corresponding epidemic of
complications of these disorders. The most prevalent complication is neuropathy, of which …