When cells are observed by phase contrast microscopy, nucleoli are among the most
conspicuous structures. The nucleolus was formally described between 1835 and 1839, but …

A veritable explosion of primary research papers within the past 10 years focuses on
nucleolar and ribosomal stress, and for good reason: with ribosome biosynthesis …

There is currently an unmet need for the supply of autologous, patient-specific stem cells for
regenerative therapies in the clinic. Mesenchymal stem cell differentiation can be driven by …

Size is a fundamental attribute impacting cellular design, fitness, and function. Size
homeostasis requires a doubling of cell mass with each division. In yeast, division is delayed …

Mesenchymal stem cells (MSCs) are typically enriched from bone marrow via isolation of the
plastic adherent, fibroblastoid cell fraction. However, plastic adherent cultures elaborated …

For over 100 years, pathologists have utilised an increase in size and number of nucleoli,
the subnuclear site of ribosome synthesis, as a marker of aggressive tumours. Despite this …

Regeneration requires signaling from a wound site for detection of the wound and a
mechanism that determines the nature of the injury to specify the appropriate regenerative …

Background Tendons are traditionally thought to consist of tenocytes only, the resident cells
of tendons; however, a recent study has demonstrated that human and mouse tendons also …

Multicellular organisms possessing relatively long life spans are subjected to diverse,
constant, and often intense intrinsic and extrinsic challenges to their survival. Animal and …

The p53-MDM2 feedback loop is vital for cell growth control and is subjected to multiple
regulations in response to various stress signals. Here we report another regulator of this …