Lupus nephritis (LN) is a form of glomerulonephritis that constitutes one of the most severe
organ manifestations of the autoimmune disease systemic lupus erythematosus (SLE). Most …

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can involve any
organ system, and may lead to significant morbidity and even mortality. This article reviews …

Systemic lupus erythematosus (SLE) is a chronic, multisystem autoimmune disease with a
highly variable clinical course. Pediatric-onset SLE (pSLE) represents 10–20% of all SLE …

Fabry disease (FD) is an X-linked lysosomal storage disease caused by alpha-
galactosidase A deficiency. The Fabry Registry is a global clinical effort to collect …

Purpose To determine if there is significant symptomatology in women with heterozygous α-
galactosidase mutations. Methods Data from medical records of the 44 heterozygous …

1 Clinical Research Centre, Kingston General Hospital, Kingston, ON. 2 Department of
Community Health and Epidemiology, Queen's University, Kingston, ON. 3 School of …

Background Systemic lupus erythematosus (SLE) is associated with significant impairment
of health-related quality of life (HR-QoL). Recently, meeting a definition of a lupus low …

Objective Childhood‐onset systemic lupus erythematosus (SLE) is a severe, lifelong,
multisystem autoimmune disease. Long‐term outcome data are limited. This study was …

Background: Fatigue is a common debilitating symptom in chronic kidney disease patients
on maintenance hemodialysis. However, little is known about its pathogenesis and …

Treat-to-target strategies have changed the approach to management of many chronic
conditions, with improvements in patient outcomes. The key to success of treat to target is …