Toxicogenomics combines transcript, protein and metabolite profiling with conventional
toxicology to investigate the interaction between genes and environmental stress in disease …

High-throughput screening (HTS) assays that measure the in vitro toxicity of environmental
compounds have been widely applied as an alternative to in vivo animal tests of chemical …

Ten years ago, the Comparative Toxicogenomics Database (CTD; http://ctdbase. org/) was
developed out of a need to formalize, harmonize and centralize the information on …

Autism spectrum disorders (ASD) are defined by behavior and diagnosed by clinical history
and observation but have no biomarkers and are presumably, etiologically and biologically …

Daphnia are already an established model species in toxicology. This freshwater crustacean
is used commonly for environmental monitoring of pollutants around the globe and plays an …

The etiology of most chronic diseases involves interactions between environmental factors
and genes that modulate important biological processes (Olden and Wilson, 2000. Nat Rev …

Read-across, ie filling toxicological data gaps by relating to similar chemicals, for which test
data are available, is usually done based on chemical similarity. Besides structure and …

Chemicals in the environment play a critical role in the etiology of many human diseases.
Despite their prevalence, the molecular mechanisms of action and the effects of chemicals …

Abstract Linkage between bis (2-ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), and
bisphenol A (BPA) co-exposure and type 2 diabetes mellitus (T2DM), as well as ability of …

Salvia miltiorrhiza, known as Danshen in Chinese, has been widely used to treat
cardiovascular diseases in China. Tanshinone I (Tan I) and cryptotanshinone (CST) are the …