Microtubules as a signal hub for axon growth in response to mechanical force
A Falconieri, A Coppini, V Raffa - Biological Chemistry, 2024 - degruyter.com
Microtubules are highly polar structures and are characterized by high anisotropy and
stiffness. In neurons, they play a key role in the directional transport of vesicles and …
stiffness. In neurons, they play a key role in the directional transport of vesicles and …
The evolution of the axonal transport toolkit
Neurons are highly polarized cells that critically depend on long‐range, bidirectional
transport between the cell body and synapse for their function. This continual and highly …
transport between the cell body and synapse for their function. This continual and highly …
[HTML][HTML] Axonal plasticity in response to active forces generated through magnetic nano-pulling
Mechanical force is crucial in guiding axon outgrowth before and after synapse formation.
This process is referred to as" stretch growth." However, how neurons transduce mechanical …
This process is referred to as" stretch growth." However, how neurons transduce mechanical …
Interplay of force and local mechanisms in axonal plasticity and beyond
A Falconieri - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2024 - Elsevier
The interactions between mechanical forces and neuronal dynamics have long intrigued
researchers. Several studies revealed that force plays a pivotal role in shaping axonal …
researchers. Several studies revealed that force plays a pivotal role in shaping axonal …
Nano-pulling stimulates axon regeneration in dorsal root ganglia by inducing stabilization of axonal microtubules and activation of local translation
A Falconieri, P Folino, L Da Palmata… - Frontiers in Molecular …, 2024 - frontiersin.org
Introduction Axonal plasticity is strongly related to neuronal development as well as
regeneration. It was recently demonstrated that active mechanical tension, intended as an …
regeneration. It was recently demonstrated that active mechanical tension, intended as an …
Manipulation of axonal outgrowth via exogenous low forces
Neurons are mechanosensitive cells. The role of mechanical force in the process of neurite
initiation, elongation and sprouting; nerve fasciculation; and neuron maturation continues to …
initiation, elongation and sprouting; nerve fasciculation; and neuron maturation continues to …