State-of-the-art of ultrasound-triggered drug delivery from ultrasound-responsive drug carriers

CH Fan, YJ Ho, CW Lin, N Wu… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction Delivering sufficient therapeutics at the target site without off-target effects is a
major goal of drug delivery technology innovation. Among the established methods …

Using imaging modalities to predict nanoparticle distribution and treatment efficacy in solid tumors: The growing role of ultrasound

MB Cooley, D Wegierak… - Wiley Interdisciplinary …, 2024 - Wiley Online Library
Nanomedicine in oncology has not had the success in clinical impact that was anticipated in
the early stages of the field's development. Ideally, nanomedicines selectively accumulate in …

Temperature sensitive nanogel-stabilized pickering emulsion of fluoroalkane for ultrasound guiding vascular embolization therapy

L Li, Y Cao, H Zhang, M Zheng, J Xing, C Zheng… - Journal of …, 2023 - Springer
Various X-ray imaging technologies like computed tomography (CT) and digital subtraction
angiography (DSA) are widely used in transcatheter arterial embolization (TAE) therapy for …

Assessing Therapeutic Nanoparticle Accumulation in Tumors Using Nanobubble-Based Contrast-Enhanced Ultrasound Imaging

MB Cooley, D Wegierak, R Perera, E Abenojar… - ACS …, 2024 - ACS Publications
This study explores the challenges associated with nanoparticle-based drug delivery to the
tumor parenchyma, focusing on the widely utilized enhanced permeability and retention …

PSMA-targeted radiopharmaceuticals for prostate cancer diagnosis and therapy

JD Oldan, F Almaguel, AF Voter, A Duran… - The Cancer …, 2024 - journals.lww.com
Prostate cancer (PCa) is the most common noncutaneous malignancy in men. Until recent
years, accurate imaging of men with newly diagnosed PCa, or recurrent or low-volume …

Pharmacokinetic modeling of PSMA‐targeted nanobubbles for quantification of extravasation and binding in mice models of prostate cancer

C Chen, R Perera, MC Kolios, H Wijkstra… - Medical …, 2022 - Wiley Online Library
Purpose Contrast‐enhanced ultrasound (CEUS) by injection of microbubbles (MBs) has
shown promise as a cost‐effective imaging modality for prostate cancer (PCa) detection …

Decorrelation time mapping as an analysis tool for Nanobubble-based contrast enhanced ultrasound imaging

D Wegierak, MB Cooley, R Perera… - … on Medical Imaging, 2024 - ieeexplore.ieee.org
Nanobubbles (NBs;~ 100–500 nm diameter) are preclinical ultrasound (US) contrast agents
that expand applications of contrast enhanced US (CEUS). Due to their sub-micron size …

Nanobubble Contrast Enhanced Ultrasound Imaging: A Review

D Wegierak, P Nittayacharn, MB Cooley… - Wiley …, 2024 - Wiley Online Library
Contrast‐enhanced ultrasound is currently used worldwide with clinical indications in
cardiology and radiology, and it continues to evolve and develop through innovative …

Life at the interface: Engineering bio‐nanomaterials through interfacial molecular self‐assembly

MA Miller, S Medina - Wiley Interdisciplinary Reviews …, 2024 - Wiley Online Library
Interfacial self‐assembly describes the directed organization of molecules and colloids at
phase boundaries. Believed to be fundamental to the inception of primordial life, interfacial …

Bohemian Rhapsody of Future Drug Delivery Systems: Rational Changes Necessary for the Next Revolution

K Park, A Otte, T Li - Molecular Pharmaceutics, 2024 - ACS Publications
Controlled drug delivery technology has matured for more than 70 years, starting from a
twice-a-day oral formulation to 6 month long-acting injectable formulations. Further …