Neurological complications and infection mechanism of SARS-COV-2
D Wan, T Du, W Hong, L Chen, H Que, S Lu… - Signal Transduction and …, 2021 - nature.com
Abstract Currently, SARS-CoV-2 has caused a global pandemic and threatened many lives.
Although SARS-CoV-2 mainly causes respiratory diseases, growing data indicate that SARS …
Although SARS-CoV-2 mainly causes respiratory diseases, growing data indicate that SARS …
The olfactory nerve is not a likely route to brain infection in COVID-19: a critical review of data from humans and animal models
R Butowt, N Meunier, B Bryche, CS von Bartheld - Acta neuropathologica, 2021 - Springer
One of the most frequent symptoms of COVID-19 is the loss of smell and taste. Based on the
lack of expression of the virus entry proteins in olfactory receptor neurons, it was originally …
lack of expression of the virus entry proteins in olfactory receptor neurons, it was originally …
Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy
Neutralizing antibodies (NAbs) are effective in treating COVID-19, but the mechanism of
immune protection is not fully understood. Here, we applied live bioluminescence imaging …
immune protection is not fully understood. Here, we applied live bioluminescence imaging …
[HTML][HTML] Endothelial cell infection and dysfunction, immune activation in severe COVID-19
Rationale: Pulmonary vascular endotheliitis, perivascular inflammation, and immune
activation are observed in COVID-19 patients. While the initial SARS-CoV-2 infection mainly …
activation are observed in COVID-19 patients. While the initial SARS-CoV-2 infection mainly …
Chronological brain lesions after SARS-CoV-2 infection in hACE2-transgenic mice
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes respiratory
disease, but it can also affect other organs including the central nervous system. Several …
disease, but it can also affect other organs including the central nervous system. Several …
Synthetic heparan sulfate mimetic pixatimod (PG545) potently inhibits SARS-CoV-2 by disrupting the spike–ACE2 interaction
SE Guimond, CJ Mycroft-West, NS Gandhi… - ACS central …, 2022 - ACS Publications
Heparan sulfate (HS) is a cell surface polysaccharide recently identified as a coreceptor with
the ACE2 protein for the S1 spike protein on SARS-CoV-2 virus, providing a tractable new …
the ACE2 protein for the S1 spike protein on SARS-CoV-2 virus, providing a tractable new …
HYBRiD: hydrogel-reinforced DISCO for clearing mammalian bodies
The recent development of solvent-and polymer-based brain-clearing techniques has
advanced our ability to visualize the mammalian nervous system in three dimensions …
advanced our ability to visualize the mammalian nervous system in three dimensions …
SARS-CoV-2 Delta variant induces enhanced pathology and inflammatory responses in K18-hACE2 mice
KS Lee, TY Wong, BP Russ, AM Horspool, OA Miller… - Plos one, 2022 - journals.plos.org
The COVID-19 pandemic has been fueled by SARS-CoV-2 novel variants of concern (VOC)
that have increased transmissibility, receptor binding affinity, and other properties that …
that have increased transmissibility, receptor binding affinity, and other properties that …
Mouse models of COVID-19 recapitulate inflammatory pathways rather than gene expression
How well mouse models recapitulate the transcriptional profiles seen in humans remains
debatable, with both conservation and diversity identified in various settings. Herein we use …
debatable, with both conservation and diversity identified in various settings. Herein we use …
Neuro-axonal damage and alteration of blood–brain barrier integrity in COVID-19 patients
Neurofilament light chain (NfL) is a specific biomarker of neuro-axonal damage. Matrix
metalloproteinases (MMPs) are zinc-dependent enzymes involved in blood–brain barrier …
metalloproteinases (MMPs) are zinc-dependent enzymes involved in blood–brain barrier …