With recent outbreaks of COVID-19 and Ebola, health and healthcare have once more
shown to be heavily burdened by the lack of generally effective anti-viral therapies. Initial …

Carbocyclic nucleosides are nucleoside analogues in which the furanosidic moiety has
been replaced by a carbocycle. Several members of this family have been isolated from …

Abstract (Carbo) nucleoside derivatives constitute an important class of pharmaceuticals, yet
there are only few convergent methods to access new analogues. Here, we report the first …

The US Food and Drug Administration approved 18 new drugs that incorporate the
cyclopropyl structural motif in the time frame from 2012 to 2018. This review provides an …

The rhodium‐catalyzed atom‐economic asymmetric N‐selective intermolecular addition of
purine derivatives to terminal allenes is reported. Branched allylic purines were obtained in …

Nucleosides are valuable bioactive molecules, which display antiviral and antitumour
activities. Diverse types of prodrugs are designed to enhance their therapeutic efficacy …

Acquired immunodeficiency syndrome (AIDS) is caused by infection with the human
immunodeficiency virus (HIV). Although treatments against HIV infection are available, AIDS …

The enantioselective synthesis of carbocyclic nucleosides through the palladium‐catalyzed
asymmetric allylic amination of alicyclic Morita‐Baylis‐Hillman (MBH) adducts with purines …

An efficient route to chiral carbocyclic nucleoside analogues containing a quaternary
stereocenter and a C C double bond has been established via a highly enantioselective …

Africa is one of the world's fastest growing economies, with South Africa having the fifth
highest worldwide pharmaceutical expenditure per capita. In recent years, several …