Nicotinamide phoshophoribosyltransferase (NAMPT) plays a key role in the replenishment
of the NAD pool in cells. This in turn makes this enzyme an important player in bioenergetics …

Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate-limiting step in NAD+
biosynthesis via salvage of NAM formed from catabolism of NAD+ by proteins with NADase …

NAD+ is mainly synthesized in human cells via the" salvage" pathways starting from
nicotinamide, nicotinic acid, or nicotinamide riboside (NR). The inhibition with FK866 of the …

Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors show importance in cancer
disease treatment while selecting compounds from a library according to inhibitory potency …

Nicotinamide phosphoribosyltransferase (NAMPT) is a key rate-limiting enzyme in the
nicotinamide adenine dinucleotide (NAD+) salvage pathway, primarily catalyzing the …

Nicotinamide phosphoribosyltransferase (Nampt) is a promising anticancer target. Virtual
screening identified a thiourea analogue, compound 5, as a novel highly potent Nampt …

A strategy for the synthesis of quinazolinones via Ru‐catalyzed redox isomerization/
acceptorless dehydrogenation was proposed and accomplished. In the presence of a …

Insulin resistance (IR) contributes to the pathophysiology of diabetes, dementia, viral
infection, and cardiovascular disease. Drug repurposing (DR) may identify treatments for IR; …

Nicotinamide adenine dinucleotide (NAD+) biosynthesis from nicotinamide is used by
mammalian cells to replenish their NAD+ stores and to avoid unwanted nicotinamide …

Prolonged inhibition of nicotinamide phosphoribosyltransferase (NAMPT) is a strategy for
targeting cancer metabolism. Many NAMPT inhibitors undergo NAMPT‐catalyzed …