Corneal nerves and their role in dry eye pathophysiology

A Vereertbrugghen, JG Galletti - Experimental Eye Research, 2022 - Elsevier
As the cornea is densely innervated, its nerves are integral not only to its structure but also to
its pathophysiology. Corneal integrity depends on a protective tear film that is maintained by …

[HTML][HTML] The calcium channel α2δ1 subunit: Interactional targets in primary sensory neurons and role in neuropathic pain

W Cui, H Wu, X Yu, T Song, X Xu, F Xu - Frontiers in Cellular …, 2021 - frontiersin.org
Neuropathic pain is mainly triggered after nerve injury and associated with plasticity of the
nociceptive pathway in primary sensory neurons. Currently, the treatment remains a …

A comprehensive review on the regulatory action of TRP channels: a potential therapeutic target for nociceptive pain

S Anand, S Rajagopal - Neuroscience Insights, 2023 - journals.sagepub.com
The transient receptor potential (TRP) superfamily of ion channels in humans comprises
voltage-gated, non-selective cation channels expressed both in excitable as well as non …

[HTML][HTML] Blue-light treatment reduces spontaneous and evoked pain in a human experimental pain model

AM Reuss, D Groos, R Scholl, M Schröter… - Pain …, 2021 - journals.lww.com
Objectives: Here, we compared the effects of blue light vs red light and thermal control on
pain sensation in a human experimental pain model. Methods: Pain, hyperalgesia, and …

Membrane potential instabilities in sensory neurons: mechanisms and pathophysiological relevance

E Velasco, JL Alvarez, VM Meseguer, J Gallar… - Pain, 2022 - journals.lww.com
Peripheral sensory neurons transduce physicochemical stimuli affecting somatic tissues into
the firing of action potentials that are conveyed to the central nervous system. This results in …