Description Proton pump inhibitors (PPIs) are among the most commonly used medications
in the world. Developed for the treatment and prevention of acid-mediated upper …

Abstract The Japanese Society of Gastroenterology (JSGE) revised the third edition of
evidence-based clinical practice guidelines for peptic ulcer disease in 2020 and created an …

Background & Aims The purpose of this review is to evaluate the risks associated with long-
term use of proton pump inhibitors (PPIs), focusing on long-term use of PPIs for three …

Peptic ulcer disease and non-steroidal anti-inflammatory drugs - PMC Back to Top Skip to
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Proton pump inhibitors (PPIs) potently inhibit gastric acid secretion and are widely used for
treatment of acid-related diseases including gastroesophageal reflux disease and …

One hundred years have passed since Felix Hoffman, working at Bayer Industries, reported
the successful synthesis of acetylsalicylic acid as the first nonsteroidal antiinflammatory drug …

Guidelines for clinical practice are intended to indicate preferred approaches to medical
problems as established by scientifically valid research. Double-blind, placebo-controlled …

The article describes the mechanisms of action, pharmacokinetics, and pharmacodynamics
of aspirin, dipyridamole, cilostazol, the thienopyridines, and the glycoprotein IIb/IIIa …

Except in rare cases, the stomach can withstand exposure to highly concentrated
hydrochloric acid, refluxed bile salts, alcohol, and foodstuffs with a wide range of …

Background The relation between H pylori infection and use of non-steroidal anti-
inflammatory drugs (NSAIDs) in the pathogenesis of peptic-ulcer disease is controversial …