Polycystic kidney disease (PKD) is a leading cause of ESRD worldwide. In PKD, excessive
cell proliferation and fluid secretion, pathogenic interactions of mutated epithelial cells with …

In the last 25 years, a number of animal models, mainly rodents, have been generated with
the goal to mimic cholestatic liver injuries and, thus, to provide in vivo tools to investigate the …

Nonhealing diabetic wounds are common complications for diabetic patients. Because
chronic hypoxia prominently delays wound healing, sustained oxygenation to alleviate …

Mechanisms of bile acid–induced (BA-induced) liver injury in cholestasis are controversial,
limiting development of new therapies. We examined how BAs initiate liver injury using …

Angiogenesis is a complicated and sequential process that plays an important role in
different physiological processes. Mesenchymal stem cells (MSCs), which are pluripotent …

Ischemic diseases, which are caused by a reduction of blood supply that results in reduced
oxygen transfer and nutrient uptake, are becoming the leading cause of disabilities and …

Graphene has been studied for its in vitro osteoinductive capacity. However, the in vivo bone
repair effects of graphene‐based scaffolds remain unknown. The aqueous soluble …

Autosomal dominant polycystic liver disease results from mutations in PRKCSH or SEC63.
The respective gene products, glucosidase IIβ and SEC63p, function in protein translocation …

Polycystic liver diseases (PLDs) are inherited genetic disorders characterized by
progressive development of intrahepatic, fluid-filled biliary cysts (more than ten), which …

Several cholangiopathies result from a perturbation of developmental processes. Most of
these cholangiopathies are characterised by the persistence of biliary structures with foetal …