The effects of exercise and activity-based physical therapy on bone after spinal cord injury

TW Sutor, J Kura, AJ Mattingly, DM Otzel… - International Journal of …, 2022 - mdpi.com
Spinal cord injury (SCI) produces paralysis and a unique form of neurogenic disuse
osteoporosis that dramatically increases fracture risk at the distal femur and proximal tibia …

Mechanism of skeletal muscle atrophy after spinal cord injury: A narrative review

X Xu, Z Talifu, CJ Zhang, F Gao, H Ke, YZ Pan… - Frontiers in …, 2023 - frontiersin.org
Spinal cord injury leads to loss of innervation of skeletal muscle, decreased motor function,
and significantly reduced load on skeletal muscle, resulting in atrophy. Factors such as …

Conductive and injectable hyaluronic acid/gelatin/gold nanorod hydrogels for enhanced surgical translation and bioprinting

EA Kiyotake, EE Thomas, HB Homburg… - … Research Part A, 2022 - Wiley Online Library
There is growing evidence indicating the need to combine the rehabilitation and
regenerative medicine fields to maximize functional recovery after spinal cord injury (SCI) …

[HTML][HTML] Pharmacologic approaches to prevent skeletal muscle atrophy after spinal cord injury

DM Otzel, HJ Kok, ZA Graham, ER Barton… - Current opinion in …, 2021 - Elsevier
Skeletal muscle atrophy is a hallmark of severe spinal cord injury (SCI) that is precipitated by
the neural insult and paralysis. Additionally, other factors may influence muscle loss …

Bone and non-contractile soft tissue changes following open kinetic chain resistance training and testosterone treatment in spinal cord injury: An exploratory study

ME Holman, G Chang, MP Ghatas, PK Saha… - Osteoporosis …, 2021 - Springer
Twenty men with spinal cord injury (SCI) were randomized into two 16-week intervention
groups receiving testosterone treatment (TT) or TT combined with resistance training (TT+ …

Do Pharmacological Treatments Act in Collaboration with Rehabilitation in Spinal Cord Injury Treatment? A Review of Preclinical Studies

S Tashiro, S Shibata, N Nagoshi, L Zhang, S Yamada… - Cells, 2024 - mdpi.com
There is no choice other than rehabilitation as a practical medical treatment to restore
impairments or improve activities after acute treatment in people with spinal cord injury …

Bone loss after severe spinal cord injury coincides with reduced bone formation and precedes bone blood flow deficits

JF Yarrow, RD Wnek, CF Conover… - Journal of Applied …, 2021 - journals.physiology.org
Diminished bone perfusion develops in response to disuse and has been proposed as a
mechanism underlying bone loss. Bone blood flow (BF) has not been investigated within the …

Transcriptomics reveals transient and dynamic muscle fibrosis and atrophy differences following spinal cord injury in rats

HJ Kok, DB Fletcher, JC Oster… - Journal of Cachexia …, 2024 - Wiley Online Library
Background The rate and magnitude of skeletal muscle wasting after severe spinal cord
injury (SCI) exceeds most other disuse conditions. Assessing the time course of molecular …

Contusion spinal cord injury upregulates p53 protein expression in rat soleus muscle at multiple timepoints but not key senescence cytokines

ZA Graham, A Goldberger, D Azulai… - Physiological …, 2020 - Wiley Online Library
To determine whether muscle disuse after a spinal cord injury (SCI) produces elevated
markers of cellular senescence and induces markers of the senescence‐associated …

Impact of rehabilitation on volumetric muscle loss in subjects with traumatic spinal cord injury: A systematic review

A de Sire, L Moggio, N Marotta, C Curci… - …, 2023 - content.iospress.com
BACKGROUND: Spinal cord injury (SCI) leads to spinal nerve fiber tract damage resulting in
functional impairments. Volumetric muscle loss (VML), a skeletal muscle volume abnormal …