[HTML][HTML] Fragile X Syndrome as an interneuronopathy: a lesson for future studies and treatments

A Tempio, A Boulksibat, B Bardoni… - Frontiers in …, 2023 - frontiersin.org
Fragile X Syndrome (FXS) is the most common form of inherited intellectual disability (ID)
and a primary genetic cause of autism spectrum disorder (ASD). FXS arises from the …

[HTML][HTML] Auditory dysfunction in animal models of autism spectrum disorder

AC Castro, P Monteiro - Frontiers in Molecular Neuroscience, 2022 - frontiersin.org
Autism spectrum disorder (ASD) is a neurodevelopmental disorder mainly characterized by
social-communication impairments, repetitive behaviors and altered sensory perception …

Elimination of perineuronal nets in CA1 disrupts GABA release and long‐term contextual fear memory retention

L Liu, Y Zhang, S Men, X Li, ST Hou, J Ju - Hippocampus, 2023 - Wiley Online Library
Perineuronal nets (PNNs) which mostly surround the parvalbumin (PV) neurons, have been
shown to play critical roles in neural plasticity. Recently, PNNs have been shown to regulate …

[HTML][HTML] Parvalbumin interneuron-derived tissue-type plasminogen activator shapes perineuronal net structure

M Lépine, S Douceau, G Devienne, P Prunotto… - BMC biology, 2022 - Springer
Abstract Background Perineuronal nets (PNNs) are specialized extracellular matrix
structures mainly found around fast-spiking parvalbumin (FS-PV) interneurons. In the adult …

[HTML][HTML] Functional consequences of postnatal interventions in a mouse model of Fragile X syndrome

M Rais, JW Lovelace, XS Shuai, W Woodard… - Neurobiology of …, 2022 - Elsevier
Abstract Background Fragile X syndrome (FXS) is a leading genetic cause of autism and
intellectual disability with cortical hyperexcitability and sensory hypersensitivity attributed to …

[HTML][HTML] Age-related upregulation of perineuronal nets on inferior collicular cells that project to the cochlear nucleus

LS Almassri, AP Ohl, MC Iafrate, AD Wade… - Frontiers in Aging …, 2023 - frontiersin.org
Introduction Disruptions to the balance of excitation and inhibition in the inferior colliculus
(IC) occur during aging and underlie various aspects of hearing loss. Specifically, the age …

[HTML][HTML] Insights into the structure and function of the hippocampus: implications for the pathophysiology and treatment of autism spectrum disorder

J Long, H Li, Y Liu, X Liao, Z Tang, K Han… - Frontiers in …, 2024 - frontiersin.org
The hippocampus is one of the brain areas affected by autism spectrum disorder (ASD).
Individuals with ASD typically have impairments in hippocampus-dependent learning …

From synaptic dysfunction to atypical emotional processing in autism

SL Reis, P Monteiro - FEBS letters, 2024 - Wiley Online Library
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition mainly
characterized by social impairments and repetitive behaviors. Among these core symptoms …

[HTML][HTML] Region-specific alterations of perineuronal net expression in postmortem autism brain tissue

C Brandenburg, GJ Blatt - Frontiers in Molecular Neuroscience, 2022 - frontiersin.org
Genetic variance in autism spectrum disorder (ASD) is often associated with mechanisms
that broadly fall into the category of neuroplasticity. Parvalbumin positive neurons and their …

Abnormal development of auditory responses in the inferior colliculus of a mouse model of Fragile X Syndrome

AO Nguyen, DK Binder, IM Ethell… - Journal of …, 2020 - journals.physiology.org
Sensory processing abnormalities are frequently associated with autism spectrum disorders,
but the underlying mechanisms are unclear. Here we studied auditory processing in a …