[HTML][HTML] Fragile X Syndrome as an interneuronopathy: a lesson for future studies and treatments
A Tempio, A Boulksibat, B Bardoni… - Frontiers in …, 2023 - frontiersin.org
Fragile X Syndrome (FXS) is the most common form of inherited intellectual disability (ID)
and a primary genetic cause of autism spectrum disorder (ASD). FXS arises from the …
and a primary genetic cause of autism spectrum disorder (ASD). FXS arises from the …
[HTML][HTML] Auditory dysfunction in animal models of autism spectrum disorder
AC Castro, P Monteiro - Frontiers in Molecular Neuroscience, 2022 - frontiersin.org
Autism spectrum disorder (ASD) is a neurodevelopmental disorder mainly characterized by
social-communication impairments, repetitive behaviors and altered sensory perception …
social-communication impairments, repetitive behaviors and altered sensory perception …
Elimination of perineuronal nets in CA1 disrupts GABA release and long‐term contextual fear memory retention
Perineuronal nets (PNNs) which mostly surround the parvalbumin (PV) neurons, have been
shown to play critical roles in neural plasticity. Recently, PNNs have been shown to regulate …
shown to play critical roles in neural plasticity. Recently, PNNs have been shown to regulate …
[HTML][HTML] Parvalbumin interneuron-derived tissue-type plasminogen activator shapes perineuronal net structure
M Lépine, S Douceau, G Devienne, P Prunotto… - BMC biology, 2022 - Springer
Abstract Background Perineuronal nets (PNNs) are specialized extracellular matrix
structures mainly found around fast-spiking parvalbumin (FS-PV) interneurons. In the adult …
structures mainly found around fast-spiking parvalbumin (FS-PV) interneurons. In the adult …
[HTML][HTML] Functional consequences of postnatal interventions in a mouse model of Fragile X syndrome
M Rais, JW Lovelace, XS Shuai, W Woodard… - Neurobiology of …, 2022 - Elsevier
Abstract Background Fragile X syndrome (FXS) is a leading genetic cause of autism and
intellectual disability with cortical hyperexcitability and sensory hypersensitivity attributed to …
intellectual disability with cortical hyperexcitability and sensory hypersensitivity attributed to …
[HTML][HTML] Age-related upregulation of perineuronal nets on inferior collicular cells that project to the cochlear nucleus
LS Almassri, AP Ohl, MC Iafrate, AD Wade… - Frontiers in Aging …, 2023 - frontiersin.org
Introduction Disruptions to the balance of excitation and inhibition in the inferior colliculus
(IC) occur during aging and underlie various aspects of hearing loss. Specifically, the age …
(IC) occur during aging and underlie various aspects of hearing loss. Specifically, the age …
[HTML][HTML] Insights into the structure and function of the hippocampus: implications for the pathophysiology and treatment of autism spectrum disorder
J Long, H Li, Y Liu, X Liao, Z Tang, K Han… - Frontiers in …, 2024 - frontiersin.org
The hippocampus is one of the brain areas affected by autism spectrum disorder (ASD).
Individuals with ASD typically have impairments in hippocampus-dependent learning …
Individuals with ASD typically have impairments in hippocampus-dependent learning …
From synaptic dysfunction to atypical emotional processing in autism
SL Reis, P Monteiro - FEBS letters, 2024 - Wiley Online Library
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition mainly
characterized by social impairments and repetitive behaviors. Among these core symptoms …
characterized by social impairments and repetitive behaviors. Among these core symptoms …
[HTML][HTML] Region-specific alterations of perineuronal net expression in postmortem autism brain tissue
C Brandenburg, GJ Blatt - Frontiers in Molecular Neuroscience, 2022 - frontiersin.org
Genetic variance in autism spectrum disorder (ASD) is often associated with mechanisms
that broadly fall into the category of neuroplasticity. Parvalbumin positive neurons and their …
that broadly fall into the category of neuroplasticity. Parvalbumin positive neurons and their …
Abnormal development of auditory responses in the inferior colliculus of a mouse model of Fragile X Syndrome
Sensory processing abnormalities are frequently associated with autism spectrum disorders,
but the underlying mechanisms are unclear. Here we studied auditory processing in a …
but the underlying mechanisms are unclear. Here we studied auditory processing in a …