Making choices: DNA replication fork recovery mechanisms

CM Kondratick, MT Washington, M Spies - Seminars in cell & …, 2021 - Elsevier
DNA replication is laden with obstacles that slow, stall, collapse, and break DNA replication
forks. At each obstacle, there is a decision to be made whether to bypass the lesion, repair …

RNA: a double-edged sword in genome maintenance

D Zong, P Oberdoerffer, PJ Batista… - Nature Reviews …, 2020 - nature.com
All organisms must safeguard the integrity of their DNA to avoid deleterious consequences
of genome instability, which have been linked to human diseases such as autoimmune …

[HTML][HTML] Guardians of the genome: BRCA2 and its partners

HP Le, WD Heyer, J Liu - Genes, 2021 - mdpi.com
The tumor suppressor BRCA2 functions as a central caretaker of genome stability, and
individuals who carry BRCA2 mutations are predisposed to breast, ovarian, and other …

Roles of homologous recombination in response to ionizing radiation-induced DNA damage

JA Nickoloff, N Sharma, CP Allen, L Taylor… - … journal of radiation …, 2023 - Taylor & Francis
Purpose Ionizing radiation induces a vast array of DNA lesions including base damage, and
single-and double-strand breaks (SSB, DSB). DSBs are among the most cytotoxic lesions …

A moving target for drug discovery: Structure activity relationship and many genome (de) stabilizing functions of the RAD52 protein

DS Bhat, MA Spies, M Spies - DNA repair, 2022 - Elsevier
BRCA-ness phenotype, a signature of many breast and ovarian cancers, manifests as
deficiency in homologous recombination, and as defects in protection and repair of …

Therapeutic disruption of RAD52–ssDNA complexation via novel drug-like inhibitors

DS Bhat, E Malacaria, LD Biagi, M Razzaghi… - NAR …, 2023 - academic.oup.com
RAD52 protein is a coveted target for anticancer drug discovery. Similar to poly-ADP-ribose
polymerase (PARP) inhibitors, pharmacological inhibition of RAD52 is synthetically lethal …

Identification of small molecule inhibitors of RAD52 for breast cancer therapy: in silico approach

M Kumar, R Dubey, P Kumar Shukla… - Journal of …, 2024 - Taylor & Francis
The breast cancer susceptibility gene 1/2 (BRCA1/2) are the key regulators in maintaining
the genomic integrity and mutations in these genes have been associated with development …

The function of RAD52 N-terminal domain is essential for viability of BRCA-deficient cells

K Hanamshet, AV Mazin - Nucleic acids research, 2020 - academic.oup.com
RAD52 is a member of the homologous recombination pathway that is important for survival
of BRCA-deficient cells. Inhibition of RAD52 leads to lethality in BRCA-deficient cells …

[HTML][HTML] Analyzing the opportunities to target DNA double-strand breaks repair and replicative stress responses to improve therapeutic index of colorectal cancer

PP Tomasini, TN Guecheva, NM Leguisamo, S Pericart… - Cancers, 2021 - mdpi.com
Simple Summary Colorectal cancer (CRC) is among the most common cancers and the third
leading cause of cancer deaths worldwide. Despite the identification of alterations in DNA …

KERA: analysis tool for multi-process, multi-state single-molecule data

J Tibbs, M Ghoneim, CC Caldwell… - Nucleic acids …, 2021 - academic.oup.com
Molecular machines within cells dynamically assemble, disassemble and reorganize.
Molecular interactions between their components can be observed at the single-molecule …