DNA replication is laden with obstacles that slow, stall, collapse, and break DNA replication
forks. At each obstacle, there is a decision to be made whether to bypass the lesion, repair …

All organisms must safeguard the integrity of their DNA to avoid deleterious consequences
of genome instability, which have been linked to human diseases such as autoimmune …

The tumor suppressor BRCA2 functions as a central caretaker of genome stability, and
individuals who carry BRCA2 mutations are predisposed to breast, ovarian, and other …

Purpose Ionizing radiation induces a vast array of DNA lesions including base damage, and
single-and double-strand breaks (SSB, DSB). DSBs are among the most cytotoxic lesions …

BRCA-ness phenotype, a signature of many breast and ovarian cancers, manifests as
deficiency in homologous recombination, and as defects in protection and repair of …

RAD52 protein is a coveted target for anticancer drug discovery. Similar to poly-ADP-ribose
polymerase (PARP) inhibitors, pharmacological inhibition of RAD52 is synthetically lethal …

The breast cancer susceptibility gene 1/2 (BRCA1/2) are the key regulators in maintaining
the genomic integrity and mutations in these genes have been associated with development …

RAD52 is a member of the homologous recombination pathway that is important for survival
of BRCA-deficient cells. Inhibition of RAD52 leads to lethality in BRCA-deficient cells …

Simple Summary Colorectal cancer (CRC) is among the most common cancers and the third
leading cause of cancer deaths worldwide. Despite the identification of alterations in DNA …

Molecular machines within cells dynamically assemble, disassemble and reorganize.
Molecular interactions between their components can be observed at the single-molecule …