Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer

SJF Cronin, S Rao, MA Tejada, BL Turnes… - Science translational …, 2022 - science.org
Increased tetrahydrobiopterin (BH4) generated in injured sensory neurons contributes to
increased pain sensitivity and its persistence. GTP cyclohydrolase 1 (GCH1) is the rate …

Classification of all pharmacological interventions tested in trials relevant to people with schizophrenia: A study‐based analysis

F Shokraneh, CE Adams - Health Information & Libraries …, 2023 - Wiley Online Library
Background Systematic reviewing is a time‐consuming and resource‐intensive process.
Information specialists are maintaining study‐based registers to facilitate efficient conduct of …