Primary aromatic amines and cancer: Novel mechanistic insights using 4-aminobiphenyl as a model carcinogen
Aromatic amines are an important class of human carcinogens found ubiquitously in our
environment. It is estimated that 1 in 8 of all known or suspected human carcinogens is or …
environment. It is estimated that 1 in 8 of all known or suspected human carcinogens is or …
A core in vitro genotoxicity battery comprising the Ames test plus the in vitro micronucleus test is sufficient to detect rodent carcinogens and in vivo genotoxins
D Kirkland, L Reeve, D Gatehouse… - Mutation Research/Genetic …, 2011 - Elsevier
In vitro genotoxicity testing needs to include tests in both bacterial and mammalian cells, and
be able to detect gene mutations, chromosomal damage and aneuploidy. This may be …
be able to detect gene mutations, chromosomal damage and aneuploidy. This may be …
Redox System and Oxidative Stress-Targeted Therapeutic Approaches in Bladder Cancer
GJ Dugbartey, S Relouw, L McFarlane, A Sener - Antioxidants, 2024 - mdpi.com
Bladder cancer (BCa) is the most common genitourinary malignancy, with a high global
incidence and recurrence rate that is paired with an increasing caregiver burden and higher …
incidence and recurrence rate that is paired with an increasing caregiver burden and higher …
Aromatic amino and nitro–amino compounds and their halogenated derivatives
YT Woo, DY Lai - Patty's toxicology, 2001 - Wiley Online Library
Aromatic amines are organic compounds that contain at least one amino group attached
directly to an aryl moiety. Aromatic amines represent one of the most important classes of …
directly to an aryl moiety. Aromatic amines represent one of the most important classes of …
Sunset Yellow induced biochemical and histopathological alterations in rat brain sub-regions
D Bhatt, K Vyas, S Singh, PJ John, IP Soni - Acta Histochemica, 2024 - Elsevier
Sunset Yellow, a synthetic orange azo food dye was examined in this study for its impact on
the Wistar rat brain sub-regions. The dye was administered orally to weanling rats at the …
the Wistar rat brain sub-regions. The dye was administered orally to weanling rats at the …
Explanation for main features of structure–genotoxicity relationships of aromatic amines by theoretical studies of their activation pathways in CYP1A2
Aromatic and heteroaromatic amines (ArNH2) represent a class of potential mutagens that
after being metabolically activated covalently modify DNA. Activation of ArNH2 in many …
after being metabolically activated covalently modify DNA. Activation of ArNH2 in many …
Effects of various plant polyphenols on bladder carcinogen benzidine-induced mutagenicity
PS Makena, KT Chung - Food and Chemical Toxicology, 2007 - Elsevier
Benzidine (Bz), a human bladder carcinogen, was strongly mutagenic to Salmonella TA102
tester strain in the Ames Salmonella microsome/mutagenicity assay in the presence of rat …
tester strain in the Ames Salmonella microsome/mutagenicity assay in the presence of rat …
Evaluating metabolite-related DNA oxidation and adduct damage from aryl amines using a microfluidic ECL array
Damage to DNA from the metabolites of drugs and pollutants constitutes a major human
toxicity pathway known as genotoxicity. Metabolites can react with metal ions and NADPH to …
toxicity pathway known as genotoxicity. Metabolites can react with metal ions and NADPH to …
4-Aminobiphenyl inhibits the DNA homologous recombination repair in human liver cells: The role of miR-630 in downregulating RAD18 and MCM8
Aminobiphenyl (4-ABP), a well-known human carcinogen, has been shown to cause
oxidative DNA damage and induce miR-630 expression in HepG2 cells treated with 18.75 …
oxidative DNA damage and induce miR-630 expression in HepG2 cells treated with 18.75 …
Theoretical studies of chemical reactivity of metabolically activated forms of aromatic amines toward DNA
The metabolism of aromatic and heteroaromatic amines (ArNH2) results in nitrenium ions
(ArNH+) that modify nucleobases of DNA, primarily deoxyguanosine (dG), by forming dG-C8 …
(ArNH+) that modify nucleobases of DNA, primarily deoxyguanosine (dG), by forming dG-C8 …