Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Lipid phosphoinositides play fundamental roles in virtually all pathways that control a cell's
decision to grow, move, divide, and die. Because of this, kinases that phosphorylate …

Lipid transfer between cell membrane bilayers at contacts between the endoplasmic
reticulum (ER) and other membranes help to maintain membrane lipid homeostasis. We …

Polyphosphoinositides are an important class of lipid that recruit specific effector proteins to
organelle membranes. One member, phosphatidylinositol 4-phosphate (PtdIns4 P) has …

Sac1 phosphoinositide (PI) phosphatases are essential regulators of PI-signaling networks.
Yeast Sac1, an integral endoplasmic reticulum (ER) membrane protein, controls PI4P levels …

Lipid phosphoinositides are master regulators of multiple cellular functions. Misregulation of
the activity of the lipid kinases that generate phosphoinositides is causative of human …

Plasma membrane phosphatidylinositol (PI) 4-phosphate (PtdIns4P) has critical functions
via both direct interactions and metabolic conversion to PI 4, 5-bisphosphate (PtdIns (4, 5) …

Background & Aims Very early onset inflammatory bowel diseases (VEOIBD), including
infant disorders, are a diverse group of diseases found in children younger than 6 years of …

Oxysterol-binding protein (OSBP)-related proteins (ORPs) are lipid-binding proteins that are
conserved from yeast to humans. They are implicated in many cellular processes including …

Abstract The phosphatidylinositol 4-kinases (PI4Ks) synthesize phosphatidylinositol 4-
phosphate (PI4P), a key member of the phosphoinositide family. PI4P defines the …