Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular
injuries in cerebral large and small vessels and is a key driver of age-related cognitive …

Cerebral small vessel disease (CSVD) results in a spectrum of neurologic, behavioral, and
cognitive sequelae, most commonly from white matter hyperintensities (WMH) of presumed …

Background Glymphatic dysfunction is a crucial pathway for dementia. Alzheimer's disease
(AD) pathologies co-existing with cerebral small vessel disease (CSVD) is the most common …

INTRODUCTION We investigated whether novel plasma biomarkers are associated with
cognition, cognitive decline, and functional independence in activities of daily living across …

Small vessel diseases (SVD) is an umbrella term including several entities affecting small
arteries, arterioles, capillaries, and venules in the brain. One of the most relevant and …

Enlarged perivascular spaces (EPVS) are common in cerebral small vessel disease (CSVD)
and have been identified as a marker of dysfunctional brain clearance. However, it remains …

Multiple injurious stimuli to the brain's endothelium results in brain endothelial cell activation
and dysfunction (BECact/dys) with upregulation of inflammatory signaling cascades and a …

Purpose We explored the interaction of optical coherence tomography (OCT) parameters
and white matter hyperintensities with cognitive measures in our older adult cohort. Methods …

Background The impact of blood–brain barrier (BBB) leakage on white matter hyperintensity
(WMH) subtypes (location) and its association with clinical factors and cognition remains …

Cerebral amyloid angiopathy (CAA) is characterized by amyloid-ß aggregation in the media
and adventitia of the leptomeningeal and cortical blood vessels. CAA is one of the strongest …