Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …

Adipose tissue, colloquially known as" fat," is an extraordinarily flexible and heterogeneous
organ. While historically viewed as a passive site for energy storage, we now appreciate that …

Neutrophils are the first responders to infection and inflammation and are thus a critical
component of innate immune defense. Understanding the behavior of neutrophils as they …

White adipose tissue, once regarded as morphologically and functionally bland, is now
recognized to be dynamic, plastic and heterogenous, and is involved in a wide array of …

Obesity-related metabolic organ inflammation contributes to cardiometabolic disorders. In
obese individuals, changes in lipid fluxes and storage elicit immune responses in the …

Obesity, characterized by chronic low-grade inflammation of the adipose tissue, is
associated with adverse coronavirus disease 2019 (COVID-19) outcomes, yet the …

Adipose tissue exhibits remarkable plasticity with capacity to change in size and cellular
composition under physiological and pathophysiological conditions. The emergence of …

Excess body weight is a global health problem due to sedentary lifestyle and unhealthy diet,
affecting 2 billion population worldwide. Obesity is a major risk factor for metabolic diseases …

Obesity usually is accompanied by inflammation of fat tissue, with a prominent role of
visceral fat. Chronic inflammation in obese fat tissue is of a lower grade than acute immune …

To date, single-cell studies of human white adipose tissue (WAT) have been based on small
cohort sizes and no cellular consensus nomenclature exists. Herein, we performed a …