Brain disorders are characterized by the progressive loss of structure and function of the
brain as a consequence of progressive degeneration and/or death of nerve cells. Aging is a …

Background Intracranial aneurysm (IA) is a disease of the vascular wall resulting in
abnormal enlargement of the vessel lumen. It is a common pathology with a prevalence of …

Mutations in the LRRK2 kinase are the most common cause of familial Parkinson's disease,
and variants increase risk for the sporadic form of the disease. LRRK2 phosphorylates …

Palmitic acid (PA) is significantly increased in the hypothalamus of mice, when fed
chronically with a high-fat diet (HFD). PA impairs insulin signaling in hypothalamic neurons …

Autophagy regulates primary cilia formation, but the underlying mechanism is not fully
understood. In this study, we identify NIMA-related kinase 9 (NEK9) as a GABARAPs …

Primary cilia project from the surface of most vertebrate cells and are key in sensing
extracellular signals and locally transducing this information into a cellular response. Recent …

Cigarette smoking has been identified as a major risk factor for osteoporosis decades ago.
Several studies have shown a direct relationship between cigarette smoking, decreased …

Cilia are hair-like membrane protrusions that emanate from the surface of most vertebrate
cells and are classified into motile and primary cilia. Motile cilia move fluid flow or propel …

Primary cilia are slender cell-surface organelles that project into the intercellular space. In
pancreatic beta cells, primary cilia coordinate a variety of cell responses including GPCR …

Primary cilia are small, special cellular organelles that provide important sensory and
signaling functions during the development of mammalian organs and coordination of …