[HTML][HTML] Protein-protein interaction networks (PPI) and complex diseases

N Safari-Alighiarloo, M Taghizadeh… - … and Hepatology from …, 2014 - ncbi.nlm.nih.gov
The physical interaction of proteins which lead to compiling them into large densely
connected networks is a noticeable subject to investigation. Protein interaction networks are …

Peptides and combination of peptides for use in immunotherapy against small cell lung cancer and other cancers

M Andrea, T Weinschenk, V Goldfinger… - US Patent …, 2019 - Google Patents
The present invention relates to peptides, proteins, nucleic acids and cells for use in
immunotherapeutic methods. In particular, the present invention relates to the immuno …

Peptides and combination of peptides for use in immunotherapy against small cell lung cancer and other cancers

M Andrea, T Weinschenk, V Goldfinger… - US Patent …, 2019 - Google Patents
The present invention relates to peptides, proteins, nucleic acids and cells for use in
immunotherapeutic methods. In particular, the present invention relates to the immuno …

Network approaches to drug discovery

N Chandra, J Padiadpu - Expert opinion on drug discovery, 2013 - Taylor & Francis
Introduction: Advances in genomics technologies are providing a very large amount of data
on genome-wide gene expression profiles, protein molecules and their interactions with …

Systems biology approach to stage-wise characterization of epigenetic genes in lung adenocarcinoma

MP Pradhan, A Desai, MJ Palakal - BMC systems biology, 2013 - Springer
Background Epigenetics refers to the reversible functional modifications of the genome that
do not correlate to changes in the DNA sequence. The aim of this study is to understand …

[HTML][HTML] An integrative network algorithm identifies age-associated differential methylation interactome hotspots targeting stem-cell differentiation pathways

J West, S Beck, X Wang, AE Teschendorff - Scientific reports, 2013 - nature.com
Epigenetic changes have been associated with ageing and cancer. Identifying and
interpreting epigenetic changes associated with such phenotypes may benefit from …

DeepSG2PPI: A protein-protein interaction prediction method based on deep learning

F Zhang, Y Zhang, X Zhu, X Chen… - … /ACM Transactions on …, 2023 - ieeexplore.ieee.org
Protein-protein interaction (PPI) plays an important role in almost all life activities. Many
protein interaction sites have been confirmed by biological experiments, but these PPI site …

CpG_MPs: identification of CpG methylation patterns of genomic regions from high-throughput bisulfite sequencing data

J Su, H Yan, Y Wei, H Liu, H Liu, F Wang… - Nucleic acids …, 2013 - academic.oup.com
High-throughput bisulfite sequencing is widely used to measure cytosine methylation at
single-base resolution in eukaryotes. It permits systems-level analysis of genomic …

The identification of age-associated cancer markers by an integrative analysis of dynamic DNA methylation changes

Y Wang, J Zhang, X Xiao, H Liu, F Wang, S Li, Y Wen… - Scientific reports, 2016 - nature.com
As one of the most widely studied epigenetic modifications, DNA methylation has an
important influence on human traits and cancers. Dynamic variations in DNA methylation …

Identifying prognostic biomarkers based on aberrant DNA methylation in kidney renal clear cell carcinoma

G Chen, Y Wang, L Wang, W Xu - Oncotarget, 2016 - pmc.ncbi.nlm.nih.gov
The outcome of kidney renal clear cell carcinoma (KIRC) differs even among individuals with
similar clinical characteristics. DNA methylation is regarded as a regulator of gene …