This is a consensus statement from an international group, mostly of clinical
endocrinologists. MEN1 and MEN2 are hereditary cancer syndromes. The commonest …

Dysregulated growth hormone (GH) hypersecretion is usually caused by a GH-secreting
pituitary adenoma and leads to acromegaly—a disorder of disproportionate skeletal, tissue …

Pituitary adenomas are one of the most frequent intracranial tumors and occur with a
prevalence of approximately 1: 1000 in the developed world. Pituitary adenomas have a …

Pituitary adenomas are common in the general population, and understanding their
molecular basis is of great interest. Combining chip-based technologies with genealogy …

The anterior pituitary gland integrates the repertoire of hormonal signals controlling thyroid,
adrenal, reproductive, and growth functions. The gland responds to complex central and …

Acromegaly is caused by excess growth hormone (GH) secretion emanating from a
somatotroph adenoma. High GH and Insulin-like growth factor-1 (IGF-1) levels lead to acral …

Context: Mutations have been identified in the aryl hydrocarbon receptor-interacting protein
(AIP) gene in familial isolated pituitary adenomas (FIPA). It is not clear, however, how this …

Context: An association between germline aryl hydrocarbon receptor-interacting protein
(AIP) gene mutations and pituitary adenomas was recently shown. Objective: The objective …

Little is known of the natural history of thymic carcinoids in multiple endocrine neoplasia type
1 (MEN1). This is important because in 1993 they were identified as a frequent cause of …

Familial isolated pituitary adenoma (FIPA) is an autosomal dominant condition with variable
genetic background and incomplete penetrance. Germline mutations of the aryl hydrocarbon …