Cisplatin as an anti-tumor drug: cellular mechanisms of activity, drug resistance and induced side effects
AM Florea, D Büsselberg - Cancers, 2011 - mdpi.com
Platinum complexes are clinically used as adjuvant therapy of cancers aiming to induce
tumor cell death. Depending on cell type and concentration, cisplatin induces cytotoxicity …
tumor cell death. Depending on cell type and concentration, cisplatin induces cytotoxicity …
The Plasma Membrane Calcium ATPases and Their Role as Major New Players in Human Disease
N Stafford, C Wilson, D Oceandy… - Physiological …, 2017 - journals.physiology.org
The Ca2+ extrusion function of the four mammalian isoforms of the plasma membrane
calcium ATPases (PMCAs) is well established. There is also ever-increasing detail known of …
calcium ATPases (PMCAs) is well established. There is also ever-increasing detail known of …
TGF‐β1 activates RSC96 Schwann cells migration and invasion through MMP‐2 and MMP‐9 activities
A Muscella, C Vetrugno, LG Cossa… - Journal of …, 2020 - Wiley Online Library
Following peripheral nerve injury, remnant Schwann cells adopt a migratory phenotype and
remodel the extracellular matrix allowing axonal regrowth. Although much evidence has …
remodel the extracellular matrix allowing axonal regrowth. Although much evidence has …
In Vitro Anticancer Activity of cis-Diammineplatinum(II) Complexes with β-Diketonate Leaving Group Ligands
JJ Wilson, SJ Lippard - Journal of medicinal chemistry, 2012 - ACS Publications
Five cationic platinum (II) complexes of general formula,[Pt (NH3) 2 (β-diketonate)] X are
reported, where X is a noncoordinating anion and β-diketonate= acetylacetonate (acac), 1 …
reported, where X is a noncoordinating anion and β-diketonate= acetylacetonate (acac), 1 …
Dietary flavonoid fisetin targets caspase-3-deficient human breast cancer MCF-7 cells by induction of caspase-7-associated apoptosis and inhibition of autophagy
The outcome of producing apoptotic defects in cancer cells is the primary obstacle that limits
the therapeutic efficacy of anticancer agents, and hence the development of novel agents …
the therapeutic efficacy of anticancer agents, and hence the development of novel agents …
Nimesulide silver metallodrugs, containing the mitochondriotropic, triaryl derivatives of pnictogen; anticancer activity against human breast cancer cells
CN Banti, C Papatriantafyllopoulou, M Manoli… - Inorganic …, 2016 - ACS Publications
Novel silver (I) metallo-drugs of the nonsteroidal anti-inflammatory drug nimesulide (nim)
and the mitochondriotropic triaryl derivatives of pnictogen ligands (tpE, E= P (tpp, tptp, or …
and the mitochondriotropic triaryl derivatives of pnictogen ligands (tpE, E= P (tpp, tptp, or …
Mitochondria-targeting anticancer metal complexes
A Erxleben - Current Medicinal Chemistry, 2019 - ingentaconnect.com
Background: Since the serendipitous discovery of the antitumor activity of cisplatin there has
been a continuous surge in studies aimed at the development of new cytotoxic metal …
been a continuous surge in studies aimed at the development of new cytotoxic metal …
Development of an experimental protocol for uptake studies of metal compounds in adherent tumor cells
AE Egger, C Rappel, MA Jakupec… - Journal of analytical …, 2009 - pubs.rsc.org
Cellular uptake is being widely investigated in the context of diverse biological activities of
metal compounds on the cellular level. However, the applied techniques differ considerably …
metal compounds on the cellular level. However, the applied techniques differ considerably …
Ligand Design for N,O- or N,N-Pyrazolone-Based Hydrazones Ruthenium(II)-Arene Complexes and Investigation of Their Anticancer Activity
Three pyrazolone-based hydrazone ligands HL′(HL′ in general; in detail, HL1= 2-((5-
hydroxo-3-methyl-1-phenyl-1 H-pyrazol-4-yl)(phenyl) methylene)-1-(2, 4-nitrophenyl) …
hydroxo-3-methyl-1-phenyl-1 H-pyrazol-4-yl)(phenyl) methylene)-1-(2, 4-nitrophenyl) …
Synthesis, characterization, DNA/BSA interactions and in vitro cytotoxicity study of palladium (II) complexes of hispolon derivatives
X Wei, Y Yang, J Ge, X Lin, D Liu, S Wang… - Journal of inorganic …, 2020 - Elsevier
Thirteen novel palladium (II) complexes of the general formula [Pd (bipy)(O, O′-dkt)](PF
6),(where bipy is 2, 2′-bipyridine and O, O′-dkt is β-diketonate ligand hispolon or its …
6),(where bipy is 2, 2′-bipyridine and O, O′-dkt is β-diketonate ligand hispolon or its …