Cisplatin as an anti-tumor drug: cellular mechanisms of activity, drug resistance and induced side effects

AM Florea, D Büsselberg - Cancers, 2011 - mdpi.com
Platinum complexes are clinically used as adjuvant therapy of cancers aiming to induce
tumor cell death. Depending on cell type and concentration, cisplatin induces cytotoxicity …

The Plasma Membrane Calcium ATPases and Their Role as Major New Players in Human Disease

N Stafford, C Wilson, D Oceandy… - Physiological …, 2017 - journals.physiology.org
The Ca2+ extrusion function of the four mammalian isoforms of the plasma membrane
calcium ATPases (PMCAs) is well established. There is also ever-increasing detail known of …

TGF‐β1 activates RSC96 Schwann cells migration and invasion through MMP‐2 and MMP‐9 activities

A Muscella, C Vetrugno, LG Cossa… - Journal of …, 2020 - Wiley Online Library
Following peripheral nerve injury, remnant Schwann cells adopt a migratory phenotype and
remodel the extracellular matrix allowing axonal regrowth. Although much evidence has …

In Vitro Anticancer Activity of cis-Diammineplatinum(II) Complexes with β-Diketonate Leaving Group Ligands

JJ Wilson, SJ Lippard - Journal of medicinal chemistry, 2012 - ACS Publications
Five cationic platinum (II) complexes of general formula,[Pt (NH3) 2 (β-diketonate)] X are
reported, where X is a noncoordinating anion and β-diketonate= acetylacetonate (acac), 1 …

Dietary flavonoid fisetin targets caspase-3-deficient human breast cancer MCF-7 cells by induction of caspase-7-associated apoptosis and inhibition of autophagy

PM Yang, HH Tseng, CW Peng… - … journal of oncology, 2012 - spandidos-publications.com
The outcome of producing apoptotic defects in cancer cells is the primary obstacle that limits
the therapeutic efficacy of anticancer agents, and hence the development of novel agents …

Nimesulide silver metallodrugs, containing the mitochondriotropic, triaryl derivatives of pnictogen; anticancer activity against human breast cancer cells

CN Banti, C Papatriantafyllopoulou, M Manoli… - Inorganic …, 2016 - ACS Publications
Novel silver (I) metallo-drugs of the nonsteroidal anti-inflammatory drug nimesulide (nim)
and the mitochondriotropic triaryl derivatives of pnictogen ligands (tpE, E= P (tpp, tptp, or …

Mitochondria-targeting anticancer metal complexes

A Erxleben - Current Medicinal Chemistry, 2019 - ingentaconnect.com
Background: Since the serendipitous discovery of the antitumor activity of cisplatin there has
been a continuous surge in studies aimed at the development of new cytotoxic metal …

Development of an experimental protocol for uptake studies of metal compounds in adherent tumor cells

AE Egger, C Rappel, MA Jakupec… - Journal of analytical …, 2009 - pubs.rsc.org
Cellular uptake is being widely investigated in the context of diverse biological activities of
metal compounds on the cellular level. However, the applied techniques differ considerably …

Ligand Design for N,O- or N,N-Pyrazolone-Based Hydrazones Ruthenium(II)-Arene Complexes and Investigation of Their Anticancer Activity

R Pettinari, F Marchetti, C Di Nicola, C Pettinari… - Inorganic …, 2018 - ACS Publications
Three pyrazolone-based hydrazone ligands HL′(HL′ in general; in detail, HL1= 2-((5-
hydroxo-3-methyl-1-phenyl-1 H-pyrazol-4-yl)(phenyl) methylene)-1-(2, 4-nitrophenyl) …

Synthesis, characterization, DNA/BSA interactions and in vitro cytotoxicity study of palladium (II) complexes of hispolon derivatives

X Wei, Y Yang, J Ge, X Lin, D Liu, S Wang… - Journal of inorganic …, 2020 - Elsevier
Thirteen novel palladium (II) complexes of the general formula [Pd (bipy)(O, O′-dkt)](PF
6),(where bipy is 2, 2′-bipyridine and O, O′-dkt is β-diketonate ligand hispolon or its …