Hosts and bacteria have coevolved over millions of years, during which pathogenic bacteria
have modified their virulence mechanisms to adapt to host defense systems. Although the …

Pseudomonas aeruginosa is often resistant to multiple antibiotics and consequently has
joined the ranks of 'superbugs' due to its enormous capacity to engender resistance. It …

How bacteria regulate, assemble and rotate flagella to swim in liquid media is reasonably
well understood. Much less is known about how some bacteria use flagella to move over the …

The growth of bacteria as structured aggregates termed biofilms leads to their protection
from harsh environmental conditions such as physical and chemical stresses, shearing …

Bacterial adhesion to biomaterials remains a major problem in the medical devices field.
Antimicrobial peptides (AMPs) are well-known components of the innate immune system …

Combination therapy is rarely used to counter the evolution of resistance in bacterial
infections. Expansion of the use of combination therapy requires knowledge of how drugs …

Antibiotic resistance among pathogenic bacteria is an ever-increasing issue worldwide.
Unfortunately, very little has been achieved in the pharmaceutical industry to combat this …

As multidrug resistance increases alarmingly, polymyxin B and colistin are increasingly
being used in the clinic to treat serious Pseudomonas aeruginosa infections. In this …

The formation of surface-attached cellular agglomerates, the so-called biofilms, contributes
significantly to bacterial resistance to antibiotics and innate host defenses. Bacterial biofilms …

Cationic antimicrobial peptides (CAMPs) are important innate immune defenses that inhibit
colonization by pathogens and contribute to clearance of infections. Gram-negative bacterial …