[HTML][HTML] Advances in understanding N-glycosylation structure, function, and regulation in health and disease
S Esmail, MF Manolson - European journal of cell biology, 2021 - Elsevier
N-linked glycosylation is a post-translational modification crucial for membrane protein
folding, stability and other cellular functions. Alteration of membrane protein N-glycans is …
folding, stability and other cellular functions. Alteration of membrane protein N-glycans is …
Targeting histone deacetylases in diseases: where are we?
Significance: Epigenetic inactivation of pivotal genes involved in cell growth is a hallmark of
human pathologies, in particular cancer. Histone acetylation balance obtained through …
human pathologies, in particular cancer. Histone acetylation balance obtained through …
BET protein inhibitor JQ1 downregulates chromatin accessibility and suppresses metastasis of gastric cancer via inactivating RUNX2/NID1 signaling
S Zhou, S Zhang, L Wang, S Huang, Y Yuan, J Yang… - Oncogenesis, 2020 - nature.com
Chromatin accessibility is critical for tumor development, whose mechanisms remain
unclear. As a crucial regulator for chromatin remodeling, BRD4 promotes tumor progression …
unclear. As a crucial regulator for chromatin remodeling, BRD4 promotes tumor progression …
Transcriptome sequencing reveals that LPS-triggered transcriptional responses in established microglia BV2 cell lines are poorly representative of primary microglia
Background Microglia are resident myeloid cells in the CNS that are activated by infection,
neuronal injury, and inflammation. Established BV2 microglial cell lines have been the …
neuronal injury, and inflammation. Established BV2 microglial cell lines have been the …
The Curtius rearrangement: applications in modern drug discovery and medicinal chemistry
The Curtius rearrangement is the thermal decomposition of an acyl azide derived from
carboxylic acid to produce an isocyanate as the initial product. The isocyanate can undergo …
carboxylic acid to produce an isocyanate as the initial product. The isocyanate can undergo …
Current paradigms in epigenetic anticancer therapeutics and future challenges
Any alteration at the genetic or epigenetic level, may result in multiplex of diseases including
tumorigenesis which ultimately results in the cancer development. Restoration of the normal …
tumorigenesis which ultimately results in the cancer development. Restoration of the normal …
Synergistic effect of JQ 1 and rapamycin for treatment of human osteosarcoma
Bromodomain and extra terminal domain (BET) proteins are important epigenetic regulators
facilitating the transcription of genes in chromatin areas linked to acetylated histones. JQ1, a …
facilitating the transcription of genes in chromatin areas linked to acetylated histones. JQ1, a …
Discovery of novel and selective SIRT6 inhibitors
MD Parenti, A Grozio, I Bauer, L Galeno… - Journal of medicinal …, 2014 - ACS Publications
SIRT6 is an NAD+-dependent deacetylase with a role in the transcriptional control of
metabolism and aging but also in genome stability and inflammation. Broad therapeutic …
metabolism and aging but also in genome stability and inflammation. Broad therapeutic …
Design, synthesis, and antitumor activity of novel compounds based on 1, 2, 4-triazolophthalazine scaffold: apoptosis-inductive and PCAF-inhibitory effects
The antitumor activity of newly synthesised triazolophthalazines (L-45 analogues) 10–32
was evaluated in human hepatocellular carcinoma (HePG-2), breast cancer (MCF-7) …
was evaluated in human hepatocellular carcinoma (HePG-2), breast cancer (MCF-7) …
Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics
G Sociali, L Galeno, MD Parenti, A Grozio… - European journal of …, 2015 - Elsevier
The NAD+-dependent sirtuin SIRT6 is highly expressed in human breast, prostate, and skin
cancer where it mediates resistance to cytotoxic agents and prevents differentiation. Thus …
cancer where it mediates resistance to cytotoxic agents and prevents differentiation. Thus …