Contractility of the myocardium engines the pumping function of the heart and is enabled by
the collective contractile activity of its muscle cells: cardiomyocytes. The effects of drugs on …

Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes (CMs)(iPSC-CMs) are
a promising cell source for myocardial regeneration, disease modeling and drug …

Producing mature and functional cardiomyocytes (CMs) by in vitro differentiation of induced
pluripotent stem cells (iPSCs) using only biochemical cues is challenging. To mimic the …

Cardiovascular diseases (CVDs) are leading causes of death worldwide, and drug-induced
cardiotoxicity is among the most common cause of drug withdrawal from the market …

Aim: Immunological checkpoint therapy is considered a powerful method for cancer therapy
and acts by re-activating autologous T cells to kill the cancer cell. Myocarditis cases have …

Aims In regenerative medicine, cellular cardiomyoplasty is one of the promising options for
treating myocardial infarction (MI); however, the efficacy of such treatment has shown to be …

Limited adult cardiac cell proliferation after cardiovascular disease, such as heart failure,
hampers regeneration, resulting in a major loss of cardiomyocytes (CMs) at the site of injury …

Doxorubicin is a commonly used chemotherapy drug that treats both adult and childhood
cancers, but its clinical usefulness is limited by doxorubicin-induced cardiotoxicity (DIC). The …

The alignment of each cell in human myocardium is considered critical for the efficient
movement of cardiac tissue. We investigated 96-well microstripe-patterned plates to align …

Breast cancer is the most commonly diagnosed cancer globally, with more than 2.3 million
cases per year and resulting in the death of 685,000 women. As a result of population …