Hypercholesterolaemia leads to cholesterol accumulation in macrophages and other
immune cells, which promotes inflammatory responses, including augmentation of Toll-like …

Atherosclerosis is the underlying cause of heart attack and stroke. Early observations that
cholesterol is a key component of arterial plaques gave rise to the cholesterol hypothesis for …

Background It is unclear whether high-density lipoprotein (HDL) cholesterol concentration
plays a causal role in atherosclerosis. A more important factor may be HDL cholesterol efflux …

Platelets have long been recognized as key players in hemostasis and thrombosis;
however, growing evidence suggests that they are also significantly involved in cancer, the …

Abstract Purpose of the Review Apolipoprotein (APO) A1, the main apolipoprotein of plasma
high-density lipoproteins (HDLs), has several well documented cardioprotective functions. A …

Platelets are small anucleate blood cells generated from megakaryocytes in the bone
marrow and cleared in the reticuloendothelial system. At the site of vascular injury, platelet …

Since the discovery in the 1970s that plasma levels of high-density lipoprotein cholesterol
(HDL-C) are inversely associated with cardiovascular outcome, it has been postulated that …

Src family kinases (SFKs) play a central role in mediating the rapid response of platelets to
vascular injury. They transmit activation signals from a diverse repertoire of platelet surface …

High-density lipoprotein (HDL) is a complex mixture of lipoproteins that is associated with
many minor proteins and lipids that influence the function of HDL. Although HDL is a …

Platelets play a critical role in atherogenesis and thrombosis-mediated myocardial ischemia,
processes that are accelerated in diabetes. Whether hyperglycemia promotes platelet …