ESKAPE pathogens, as priority 1 and 2 pathogens, are prevalent infectious agents
associated with high morbidity and mortality. ESKAPE can cause broad-spectrum diseases …

The need to overcome ever-increasing cases of antifungal resistance and circumvent side
effects and drug interactions related to currently available drugs has impelled the demand to …

Fungal infections have become a major public health issue with dramatically increasing
morbidity, mortality and cost of hospitalization. Azole antifungals are first‐in‐line medications …

Acetaminophen (AP) is a popularly recommended over-the-counter analgesic–antipyretic in
clinical use. However, the drug is handicapped by the occurrence of hepatotoxic insult …

Novel series of triazole-benzoxazole hybrid compounds (7a-7i) have been synthesized via
click chemistry between different azide derivatives and benzoxazole terminal alkynes …

Background: Reduced efficacy of the available antifungal drugs is the major public health
concern of the population all over the world. Despite significant advances in the treatment of …

Cytochrome P450 3A4, the most abundant form of isoenzyme, in combination with several
other isoforms, metabolizes lignocaine into mono-ethylglycine xylidide (MEGX) and …

The novel series of phthalimide-1 H-1, 2, 3-triazole derivatives (6a–o) was created by
combining various azide derivatives with an N-methylene bond using click chemistry. N …

Abstract A series of new 2‐(2‐ethylpyridin‐4‐yl)‐4‐methyl‐N‐phenylthiazole‐5‐
carboxamide derivatives (5a‐l) were synthesized and evaluated for their in vitro …

Como se ha indicado en la introducción general de esta Tesis Doctoral, la síntesis y el uso
en diferentes campos de los complejos de metales de transición con ligandos βlactámicos …