Recent progress of the development of dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus

N Li, LJ Wang, B Jiang, X Li, C Guo, S Guo… - European Journal of …, 2018 - Elsevier
Diabetes is a fast growing chronic metabolic disorder around the world. Dipeptidyl peptidase-
4 (DPP-4) is a new promising target during type 2 diabetes glycemic control. Thus, a number …

[HTML][HTML] Diagnostic and therapeutic potential of protease inhibition

N Ćwilichowska, KW Świderska, A Dobrzyń… - Molecular Aspects of …, 2022 - Elsevier
Proteases are enzymes that hydrolyze peptide bonds in proteins and peptides; thus, they
control virtually all biological processes. Our understanding of protease function has …

A review upon medicinal perspective and designing rationale of DPP-4 inhibitors

S Kumar, A Mittal, A Mittal - Bioorganic & Medicinal Chemistry, 2021 - Elsevier
Abstract Type 2 Diabetes Mellitus (T2DM) is one of the highly prevalence disorder and
increasing day by day worldwidely. T2DM is a metabolic disorder, which is characterized by …

Synthesis, in-Silico studies and biological evaluation of pyrimidine based thiazolidinedione derivatives as potential anti-diabetic agent

S Amin, KA Sheikh, A Iqubal, MA Khan… - Bioorganic …, 2023 - Elsevier
Despite the advancements in the management of Diabetes mellitus, the design and
synthesis of drug molecule which ameliorates the hyperglycemia and associated secondary …

Rational design and synthesis of new tetralin-sulfonamide derivatives as potent anti-diabetics and DPP-4 inhibitors: 2D & 3D QSAR, in vivo radiolabeling and bio …

SS Abd El-Karim, MM Anwar, YM Syam, MA Nael… - Bioorganic …, 2018 - Elsevier
Abstract Type 2 diabetes (T2D) is a severe disease and it is one of the most raising
problems worldwide. This study deals with design, synthesis and in vivo determination of a …

Synthesis, molecular modelling studies and ADME prediction of benzothiazole clubbed oxadiazole-Mannich bases, and evaluation of their anti-diabetic activity …

R Bhutani, DP Pathak, G Kapoor, A Husain, R Kant… - Bioorganic …, 2018 - Elsevier
A small library of new benzothiazole clubbed oxadiazole-Mannich bases (M-1 to M-22) were
synthesized and characterized by IR, NMR, Mass and Elemental analysis results. Molecular …

Medicinal chemistry of non-peptidomimetic dipeptidyl peptidase IV (DPP IV) inhibitors for treatment of Type-2 diabetes mellitus: Insights on recent development

JP Ambhore, PR Laddha, A Nandedkar… - Journal of Molecular …, 2023 - Elsevier
Nowadays, dipeptidyl peptidase-IV (DPP-IV) is emerging as a hopeful drug target for treating
Type 2 diabetic mellitus (T2DM). Currently marketed DPP-IV inhibitors work by lowering the …

[HTML][HTML] Recent advances in the synthesis and utility of thiazoline and its derivatives

S Kumar, A Arora, S Sapra, R Kumar, BK Singh… - RSC …, 2024 - pubs.rsc.org
Thiazolines and their derivatives hold significant importance in the field of medicinal
chemistry due to their promising potential as pharmaceutical agents. These molecular …

Fabrication of furan-functionalized quinazoline hybrids: their antibacterial evaluation, quantitative proteomics, and induced phytopathogen morphological variation …

QS Long, LW Liu, YL Zhao, PY Wang… - Journal of agricultural …, 2019 - ACS Publications
The limited number of agrochemicals targeting plant bacterial diseases has driven us to
develop highly efficient, low-cost, and versatile antibacterial alternatives. Herein, a novel …

The research progress of DPP-4 inhibitors

ZG Sun, ZN Li, HL Zhu - Mini Reviews in Medicinal Chemistry, 2020 - ingentaconnect.com
Diabetes mellitus (DM) is a metabolic disease, and diabetes patients have long-term higher
blood sugar levels than standard. Most people with diabetes have complications that greatly …