Understanding the brain requires studying its multiscale interactions from molecules to
networks. The increasing availability of large-scale datasets detailing brain circuit …

The need for reproducible, credible, multiscale biological modeling has led to the
development of standardized simulation platforms, such as the widely-used NEURON …

We developed a detailed model of macaque auditory thalamocortical circuits, including
primary auditory cortex (A1), medial geniculate body (MGB), and thalamic reticular nucleus …

Pain-related sensory input is processed in the spinal dorsal horn (SDH) before being
relayed to the brain. That processing profoundly influences whether stimuli are correctly or …

The primary somatosensory cortex (S1) of mammals is critically important in the perception
of touch and related sensorimotor behaviors. In 2015, the Blue Brain Project (BBP) …

Background The explosive growth of next-generation sequencing data has resulted in ultra-
large-scale datasets and significant computational challenges. As the cost of next …