Membrane lipid composition: effect on membrane and organelle structure, function and compartmentalization and therapeutic avenues
D Casares, PV Escribá, CA Rosselló - International journal of molecular …, 2019 - mdpi.com
Biological membranes are key elements for the maintenance of cell architecture and
physiology. Beyond a pure barrier separating the inner space of the cell from the outer, the …
physiology. Beyond a pure barrier separating the inner space of the cell from the outer, the …
[HTML][HTML] Homeoviscous adaptation and the regulation of membrane lipids
Biological membranes are complex and dynamic assemblies of lipids and proteins.
Poikilothermic organisms including bacteria, fungi, reptiles, and fish do not control their body …
Poikilothermic organisms including bacteria, fungi, reptiles, and fish do not control their body …
APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia
The E4 allele of the apolipoprotein E gene (APOE) has been established as a genetic risk
factor for many diseases including cardiovascular diseases and Alzheimer's disease (AD) …
factor for many diseases including cardiovascular diseases and Alzheimer's disease (AD) …
Lipid landscapes and pipelines in membrane homeostasis
JCM Holthuis, AK Menon - Nature, 2014 - nature.com
The lipid composition of cellular organelles is tailored to suit their specialized tasks. A
fundamental transition in the lipid landscape divides the secretory pathway in early and late …
fundamental transition in the lipid landscape divides the secretory pathway in early and late …
Activation of the unfolded protein response by lipid bilayer stress
K Halbleib, K Pesek, R Covino, HF Hofbauer… - Molecular cell, 2017 - cell.com
The unfolded protein response (UPR) is a conserved homeostatic program that is activated
by misfolded proteins in the lumen of the endoplasmic reticulum (ER). Recently, it became …
by misfolded proteins in the lumen of the endoplasmic reticulum (ER). Recently, it became …
Regulation of lipid saturation without sensing membrane fluidity
Cells maintain membrane fluidity by regulating lipid saturation, but the molecular
mechanisms of this homeoviscous adaptation remain poorly understood. We have …
mechanisms of this homeoviscous adaptation remain poorly understood. We have …
A sub-nanometre view of how membrane curvature and composition modulate lipid packing and protein recruitment
Two parameters of biological membranes, curvature and lipid composition, direct the
recruitment of many peripheral proteins to cellular organelles. Although these traits are often …
recruitment of many peripheral proteins to cellular organelles. Although these traits are often …
The functional proteome landscape of Escherichia coli
Recent developments in high-throughput reverse genetics, have revolutionized our ability to
map gene function and interactions,,–. The power of these approaches depends on their …
map gene function and interactions,,–. The power of these approaches depends on their …
Role for lipid droplet biogenesis and microlipophagy in adaptation to lipid imbalance in yeast
The immediate responses to inhibition of phosphatidylcholine (PC) biosynthesis in yeast are
altered phospholipid levels, slow growth, and defects in the morphology and localization of …
altered phospholipid levels, slow growth, and defects in the morphology and localization of …
From zero to six double bonds: phospholipid unsaturation and organelle function
Cellular phospholipids (PLs) differ by the nature of their polar heads as well as by the length
and unsaturation level of their fatty acyl chains. We discuss how the ratio between saturated …
and unsaturation level of their fatty acyl chains. We discuss how the ratio between saturated …