Transplanting neural progenitor cells to restore connectivity after spinal cord injury

I Fischer, JN Dulin, MA Lane - Nature Reviews Neuroscience, 2020 - nature.com
Spinal cord injury remains a scientific and therapeutic challenge with great cost to
individuals and society. The goal of research in this field is to find a means of restoring lost …

Therapeutic potential of neurotrophins for repair after brain injury: a helping hand from biomaterials

J Houlton, N Abumaria, SFR Hinkley… - Frontiers in …, 2019 - frontiersin.org
Stroke remains the leading cause of long-term disability with limited options available to aid
in recovery. Significant effort has been made to try and minimize neuronal damage following …

Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease

M Blurton-Jones, M Kitazawa… - Proceedings of the …, 2009 - National Acad Sciences
Neural stem cell (NSC) transplantation represents an unexplored approach for treating
neurodegenerative disorders associated with cognitive decline such as Alzheimer disease …

Neuroprotective strategies after neonatal hypoxic ischemic encephalopathy

BJ Dixon, C Reis, WM Ho, J Tang… - International journal of …, 2015 - mdpi.com
Neonatal hypoxic ischemic encephalopathy (HIE) is a devastating disease that primarily
causes neuronal and white matter injury and is among the leading cause of death among …

Cell-based drug delivery

F Pierigè, S Serafini, L Rossi, M Magnani - Advanced drug delivery reviews, 2008 - Elsevier
Drug delivery has been greatly improved over the years by means of chemical and physical
agents that increase bioavailability, improve pharmacokinetic and reduce toxicities. At the …

Cell based therapies for ischemic stroke: from basic science to bedside

X Liu, R Ye, T Yan, SP Yu, L Wei, G Xu, X Fan… - Progress in …, 2014 - Elsevier
Cell therapy is emerging as a viable therapy to restore neurological function after stroke.
Many types of stem/progenitor cells from different sources have been explored for their …

The preventive and therapeutic effects of intravenous human adipose-derived stem cells in Alzheimer's disease mice

S Kim, KA Chang, JA Kim, HG Park, JC Ra, HS Kim… - 2012 - journals.plos.org
Alzheimer's disease (AD) is characterized by the accumulation of amyloid plaques and
neurofibrillary tangles accompanied by cognitive dysfunction. The aim of the present study …

Cell therapy for neonatal hypoxia–ischemia and cerebral palsy

L Bennet, S Tan, L Van den Heuij, M Derrick… - Annals of …, 2012 - Wiley Online Library
Perinatal hypoxic–ischemic brain injury remains a major cause of cerebral palsy. Although
therapeutic hypothermia is now established to improve recovery from hypoxia–ischemia (HI) …

Drug delivery with living cells

LAL Fliervoet, E Mastrobattista - Advanced drug delivery reviews, 2016 - Elsevier
The field of drug delivery has grown tremendously in the past few decades by developing a
wide range of advanced drug delivery systems. An interesting category is cell-based drug …

Functions of neurotrophins and growth factors in neurogenesis and brain repair

SLB Oliveira, MM Pillat, A Cheffer, C Lameu… - Cytometry Part …, 2013 - Wiley Online Library
The identification and isolation of multipotent neural stem and progenitor cells in the brain,
giving rise to neurons, astrocytes, and oligodendrocytes initiated many studies in order to …