Since the introduction of insulin almost a century ago, more than 80 peptide drugs have
reached the market for a wide range of diseases, including diabetes, cancer, osteoporosis …

The gonadotropin-releasing hormone (GnRH) neuronal network generates pulse and surge
modes of gonadotropin secretion critical for puberty and fertility. The arcuate nucleus …

This review provides an outline of how our understanding of the neuroendocrine control of
the hypothalamo-pituitary–gonadal axis has evolved since the publication of Geoffrey Harris' …

BACKGROUND Human reproduction depends on an intact hypothalamic–pituitary–gonadal
(HPG) axis. Hypothalamic gonadotrophin-releasing hormone (GnRH) has been recognized …

Endometriosis and polycystic ovary syndrome (PCOS) are two common female reproductive
disorders with a significant impact on the health and quality of life of women affected. A …

Central precocious puberty (CPP) results from early activation of the hypothalamic‐pituitary‐
gonadal (HPG) axis. The current state of knowledge of the complex neural network acting at …

Background Kisspeptin is the leading upstream regulator of pulsatile and surge
Gonadotrophin-Releasing Hormone secretion (GnRH) in the hypothalamus, which acts as …

Women's health disorders such as uterine fibroids and endometriosis are currently treated
by GnRH modulators that effectively suppress the hypothalamic-pituitary-gonadal axis. The …

Neuropeptides play a critical role in regulating animal reproduction. In vertebrates, GnRH,
GnIH and kisspeptin are the key neuropeptide hormones of the reproductive axis, however …

Although significant progress has been made in the implementation of new breast cancer
treatments over the last three decades, this neoplasm annually continues to show high …