Function and dynamics of the intrinsically disordered carboxyl terminus of β2 adrenergic receptor
J Heng, Y Hu, G Pérez-Hernández, A Inoue… - Nature …, 2023 - nature.com
Advances in structural biology have provided important mechanistic insights into signaling
by the transmembrane core of G-protein coupled receptors (GPCRs); however, much less is …
by the transmembrane core of G-protein coupled receptors (GPCRs); however, much less is …
Time-resolved cryo-EM of G-protein activation by a GPCR
MM Papasergi-Scott, G Pérez-Hernández, H Batebi… - Nature, 2024 - nature.com
G-protein-coupled receptors (GPCRs) activate heterotrimeric G proteins by stimulating
guanine nucleotide exchange in the Gα subunit. To visualize this mechanism, we developed …
guanine nucleotide exchange in the Gα subunit. To visualize this mechanism, we developed …
MutationExplorer: a webserver for mutation of proteins and 3D visualization of energetic impacts
M Philipp, CW Moth, N Ristic, JKS Tiemann… - Nucleic Acids …, 2024 - academic.oup.com
The possible effects of mutations on stability and function of a protein can only be
understood in the context of protein 3D structure. The MutationExplorer webserver maps …
understood in the context of protein 3D structure. The MutationExplorer webserver maps …
Structural Characteristics of PON1 with Leu55Met and Gln192Arg Variants Influencing Oxidative-Stress-Related Diseases: An Integrated Molecular Modeling and …
Background and Objectives: PON1 is a multi-functional antioxidant protein that hydrolyzes a
variety of endogenous and exogenous substrates in the human system. Growing evidence …
variety of endogenous and exogenous substrates in the human system. Growing evidence …
Virtual screening and molecular dynamics simulation of natural compounds as potential inhibitors of serine/threonine kinase 16 for anticancer drug discovery
D Al-Fahad, G Ropón-Palacios, DA Omoboyowa… - Molecular Diversity, 2024 - Springer
Abstract Serine/threonine kinase 16 (STK 16) is involved in many facets of cellular
regulation; activation of STK 16 plays a crucial role in the migration of cancer cells …
regulation; activation of STK 16 plays a crucial role in the migration of cancer cells …
Structural Dynamics and Bioinformatics Studies of the NSP10 from SARS-CoV-2
H Wang - 2023 - discovery.ucl.ac.uk
The coronavirus SARS-CoV-2 protects its RNA from being recognized by the host immune
responses by methylation of its 5'end, also known as capping. This process is carried out by …
responses by methylation of its 5'end, also known as capping. This process is carried out by …
Synthesis, molecular dynamics simulation, and evaluation of biological activity of novel flurbiprofen and ibuprofen‐like compounds
The frequent use of anti‐inflammatory drugs and the side effects of existing drugs keep the
need for new compounds constant. For this purpose, flurbiprofen and ibuprofen‐like …
need for new compounds constant. For this purpose, flurbiprofen and ibuprofen‐like …