Gene therapy by expression constructs or down-regulation of certain genes has shown great
potential for the treatment of various diseases. The wide clinical application of nucleic acid …

Although chemotherapy can improve the overall survival and prognosis of cancer patients,
chemoresistance remains an obstacle due to the diversity, heterogeneity, and adaptability to …

Abstract Poly (amidoamine)(PAMAM) dendrimers are well-defined, highly branched
macromolecules with numerous active amine groups on the surface. Because of their …

Simple Summary Recently, our understanding of PFK-2 isozymes, particularly with regards
to their roles in cancer, has developed significantly. This review aims to compile the most …

Nanoparticle drug delivery systems have proved anti-tumor effects; however, they are not
widely used in tumor therapy due to insufficient ability to target specific sites, multidrug …

Exosomes are endogenous extracellular vesicles (30-100 nm) composed with membrane
lipid bilayer which carry vesicular proteins, enzymes, mRNA, miRNA and nucleic acids. They …

The adverse side effects and toxicity caused by the non-targeted delivery of doxorubicin has
emphasized the demand of emerging a targeted delivery system. The goal of this study is to …

The objective of the present study was to fabricate microneedles for delivering lipophilic
active ingredients (APIs) using digital light processing (DLP) printing technology and quality …

Nanocarriers passively accumulate in solid tumors through irregular wide fenestrations in
neovasculature and increased retention due to poor lymphatic drainage, a phenomenon …

Psoriasis is a chronic autoimmune disorder that affects the skin to alter its structure and
physiology and express the phenotypic function of abnormal epidermal cell growth through …