Mechanisms governing activity-dependent synaptic pruning in the developing mammalian CNS

TE Faust, G Gunner, DP Schafer - Nature Reviews Neuroscience, 2021 - nature.com
Almost 60 years have passed since the initial discovery by Hubel and Wiesel that changes
in neuronal activity can elicit developmental rewiring of the central nervous system (CNS) …

mTOR at the nexus of nutrition, growth, ageing and disease

GY Liu, DM Sabatini - Nature reviews Molecular cell biology, 2020 - nature.com
The mTOR pathway integrates a diverse set of environmental cues, such as growth factor
signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half …

Neurodevelopmental disorders: from genetics to functional pathways

I Parenti, LG Rabaneda, H Schoen, G Novarino - Trends in Neurosciences, 2020 - cell.com
Neurodevelopmental disorders (NDDs) are a class of disorders affecting brain development
and function and are characterized by wide genetic and clinical variability. In this review, we …

Consensus paper: cerebellum and social cognition

F Van Overwalle, M Manto, Z Cattaneo, S Clausi… - The Cerebellum, 2020 - Springer
The traditional view on the cerebellum is that it controls motor behavior. Although recent
work has revealed that the cerebellum supports also nonmotor functions such as cognition …

The cerebellum and cognition

JD Schmahmann - Neuroscience letters, 2019 - Elsevier
What the cerebellum does to sensorimotor and vestibular control, it also does to cognition,
emotion, and autonomic function. This hypothesis is based on the theories of dysmetria of …

Role of gut microbiome in autism spectrum disorder and its therapeutic regulation

MA Taniya, HJ Chung, A Al Mamun, S Alam… - Frontiers in cellular …, 2022 - frontiersin.org
Autism spectrum disorder (ASD) is a neurological disorder that affects normal brain
development. The recent finding of the microbiota–gut–brain axis indicates the bidirectional …

Cerebellar modulation of the reward circuitry and social behavior

I Carta, CH Chen, AL Schott, S Dorizan, K Khodakhah - Science, 2019 - science.org
INTRODUCTION Although the cerebellum has long been considered to be a purely motor
structure, recent studies have revealed that it also has critical nonmotor functions. Cerebellar …

Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications

CC Jiang, LS Lin, S Long, XY Ke, K Fukunaga… - Signal transduction and …, 2022 - nature.com
Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …

The theory and neuroscience of cerebellar cognition

JD Schmahmann, X Guell, CJ Stoodley… - Annual review of …, 2019 - annualreviews.org
Cerebellar neuroscience has undergone a paradigm shift. The theories of the universal
cerebellar transform and dysmetria of thought and the principles of organization of cerebral …

Regulation of autism-relevant behaviors by cerebellar–prefrontal cortical circuits

E Kelly, F Meng, H Fujita, F Morgado, Y Kazemi… - Nature …, 2020 - nature.com
Cerebellar dysfunction has been demonstrated in autism spectrum disorders (ASDs);
however, the circuits underlying cerebellar contributions to ASD-relevant behaviors remain …