Studies of the neurobiological predisposition to consume alcohol (ethanol) and to transition
to uncontrolled drinking behavior (alcoholism), as well as studies of the effects of alcohol on …

The development of alcohol dependence is posited to involve numerous changes in brain
chemistry (ie, neurotransmission) that lead to physiological signs of withdrawal upon …

The purpose of this review is to present animal research models that can be used to screen
and/or repurpose medications for the treatment of alcohol abuse and dependence. The …

The purpose of this review paper is to present evidence that rat animal models of alcoholism
provide an ideal platform for developing and screening medications that target alcohol …

The present paper summarizes the preclinical and clinical studies conducted to define the
“anti-alcohol” pharmacological profile of the prototypic GABAB receptor agonist, baclofen …

This paper summarizes the several lines of experimental evidence demonstrating the ability
of the prototypic GABAB receptor agonist, baclofen, to suppress multiple alcohol-related …

The present paper summarizes experimental data demonstrating the reducing effect of direct
agonists and positive allosteric modulators (PAMs) of the γ-aminobutyric acidB (GABAB) …

Preclinical research over the past several decades has demonstrated a role for the γ-
aminobutyric acidB (GABAB) receptor in alcohol use disorder (AUD). This chapter offers an …

Aims The effects of alcohol on gamma-aminobutyric acid (GABA) transmission are key for
the development and maintenance of alcohol use disorder (AUD). Previous research …

Background Administration of the GABAB receptor agonist, baclofen, and positive allosteric
modulator, GS 39783, has been repeatedly reported to suppress multiple alcohol‐related …