The relationships between inflammation and cancer are varied and complex. An important
connection linking inflammation to cancer development is DNA damage. During …

Sepsis occurs when an infection exceeds local tissue containment and induces a series of
dysregulated physiologic responses that result in organ dysfunction. A subset of patients …

Cancer is the second leading cause of mortality globally which remains a continuing threat
to human health today. Drug insensitivity and resistance are critical hurdles in cancer …

Recent studies have indicated that the regulation of innate immunity and energy metabolism
are connected together through an antagonistic crosstalk between NF-κB and SIRT1 …

With no approved pharmacological treatment, nonalcoholic fatty liver disease (NAFLD) is
now the most common cause of chronic liver disease in Western countries and its worldwide …

Sirtuin 1 (SIRT1) regulates inflammation, aging (life span and health span), calorie
restriction/energetics, mitochondrial biogenesis, stress resistance, cellular senescence …

Inhibitors of poly-ADP-ribose polymerase (PARP) family proteins are currently in clinical
trials as cancer therapeutics, yet the specificity of many of these compounds is unknown …

The aim of this article is to describe the current and potential clinical translation of
pharmacological inhibitors of poly (ADP-ribose) polymerase (PARP) for the therapy of …

The recent clinical availability of the PARP inhibitor olaparib (Lynparza) opens the door for
potential therapeutic repurposing for non‐oncological indications. Considering (a) the …

Intercellular transfer of microRNAs can mediate communication between critical effector
cells. We hypothesized that transfer of neutrophil-derived microRNAs to pulmonary epithelial …