Stem cells play central roles in tissue development, homeostasis, and regeneration.
Decades of scientific research have uncovered processes of stem cell decline in tissue and …

Oxysterols are cholesterol metabolites that can be produced through enzymatic or radical
processes. They constitute a large family of lipids (ie the oxysterome) involved in a plethora …

It is estimated that 2% to 3% of the population are currently prescribed systemic or topical
glucocorticoid treatment. The potent anti-inflammatory action of glucocorticoids to deliver …

The skin provides the primary protection for the body against external injuries and is
essential in the maintenance of general homeostasis. During ageing, resident cells become …

The primary adrenal cortical steroid hormones, aldosterone, and the glucocorticoids cortisol
and corticosterone, act through the structurally similar mineralocorticoid (MR) and …

Normal aging results in subtle changes both in ACTH and cortisol secretion. Most notable is
the general increase in mean daily serum cortisol levels in the elderly, without a noteworthy …

The mineralocorticoid receptor (MR) and its ligand aldosterone are the principal modulators
of hormone-regulated renal sodium reabsorption. In addition to the kidney, there are several …

The adverse metabolic effects of prescribed and endogenous glucocorticoid (GC) excess,
Cushing syndrome, create a significant health burden. We found that tissue regeneration of …

Chronologically-aged skin displays multiple functional changes in both the dermis and the
epidermis. It appears that epidermal dysfunction, compromised permeability homeostasis …

Computational methods are well-established tools in the drug discovery process and can be
employed for a variety of tasks. Common applications include lead identification and scaffold …