The recent outbreak of coronavirus disease 2019 (COVID-19) highlights an urgent need for
therapeutics. Through a series of drug repurposing screening campaigns, niclosamide, an …

Aim/purpose Niclosamide (NCL) is an anthelminthic drug, which is widely used to treat
various diseases due to its pleiotropic anti-inflammatory and antiviral activities. NCL …

Introducing novel strategies, concepts, and technologies that speed up drug discovery and
the drug development cycle is of great importance both in the highly competitive …

Human adenoviruses (HAdV) are ubiquitous human pathogens that cause a significant
burden of respiratory, ocular, and gastrointestinal illnesses. Although HAdV infections are …

Oncolytic viruses are naturally occurring or genetically engineered viruses that can replicate
preferentially in tumor cells and inhibit tumor growth. These viruses have been considered …

COVID-19 is a rapidly evolving emergency, for which there have been no specific
medication found yet. Therefore, it is necessary to find a solution for this ongoing pandemic …

Highlights•Broad-spectrum antivirals target≥ 3 viral diseases.•108 safe-in-man broad-
spectrum antiviral agents were identified.•These agents could reinforce the arsenal of …

Since the early days of 2020, the severe acute respiratory syndrome coronavirus 2
pandemic has become a global health concern. Currently, some therapies and vaccines …

Since time immemorial human beings have constantly been fighting against viral infections.
The ongoing and devastating coronavirus disease 2019 pandemic represents one of the …

Hepatitis E virus (HEV) infection can cause severe acute hepatitis in pregnant women and
chronic infection in immunocompromised patients, promoting the development of effective …