While antiretroviral drugs have transformed the lives of HIV-infected individuals, chronic
treatment is required to prevent rebound from viral reservoir cells. People living with HIV …

Adoptive T cell therapy using TCR transgenic autologous T cells has shown great potential
for the treatment of tumor patients. Thorough characterization of genetically reprogrammed T …

Cytotoxic CD8+ T cells recognize and eliminate infected or malignant cells that present
peptide epitopes derived from intracellularly processed antigens on their surface. However …

Select CMV epitopes drive life-long CD8+ T cell memory inflation, but the extent of CD4
memory inflation is poorly studied. CD4+ T cells specific for human CMV (HCMV) are …

Chimeric antigen receptor (CAR)-T cell immunotherapy is under intense preclinical and
clinical investigation, and it involves a rapidly increasing portfolio of novel target antigens …

The HIV accessory protein Nef modulates key immune evasion and pathogenic functions,
and its encoding gene region exhibits high sequence diversity. Given the recent …

SERINC5 is a multipass intrinsic membrane protein that suppresses HIV-1 infectivity when
incorporated into budding virions. The HIV-1 Nef virulence factor prevents viral incorporation …

HIV-1 Nef enhances virion infectivity by counteracting host restriction factor SERINC5;
however, the impact of natural Nef polymorphisms on this function is largely unknown. We …

The HIV-1 Nef accessory factor is critical to the viral life cycle in vivo and promotes immune
escape of infected cells via downregulation of cell-surface MHC-I. Previously, we discovered …

Nef is an HIV-encoded accessory protein that enhances pathogenicity by down-regulating
major histocompatibility class I (MHC-I) expression to evade killing by cytotoxic T …