Low SARS-CoV-2 viral load among vaccinated individuals infected with Delta B. 1.617. 2 and Omicron BA. 1.1. 529 but not with Omicron BA. 1.1 and BA. 2 variants

ST Selvavinayagam, YK Yong, N Joseph… - Frontiers in public …, 2022 - frontiersin.org
The rapid spread of SARS-CoV-2 variants in the global population is indicative of the
development of selective advantages in emerging virus strains. Here, we performed a case …

[HTML][HTML] Immunological storm and multiple organ damage by COVID-19

AY Arafath, SA Fathima, A Prabhakaran, S Hassan… - Medicine in Omics, 2024 - Elsevier
The official recording outbreak COVID-19 virus was in Dec 2019. When it affects humans, it
affects almost all age groups, especially aged people. COVID-19 becomes a Global …

A hijack mechanism of Indian SARS-CoV-2 isolates for relapsing contemporary antiviral therapeutics

R Prathiviraj, S Saranya, M Bharathi… - Computers in biology and …, 2021 - Elsevier
Abstract Coronavirus disease (COVID-19) rapidly expands to a global pandemic and its
impact on public health varies from country to country. It is caused by a new virus severe …

Structure, function and evolution of Clostridium botulinum C2 and C3 toxins: Insight to poultry and veterinary vaccines

P Chellapandi, A Prisilla - Current Protein and Peptide Science, 2017 - ingentaconnect.com
Clostridium botulinum group III strains are able to produce cytotoxins, C2 toxin and C3
exotoxin, along with botulinum neurotoxin types C and D. C2 toxin and C3 exotoxin …

[HTML][HTML] Network pharmacology based analysis of Astragalus propinquus components for the treatment of rheumatoid arthritis and diabetes

TR Sivakumar, D Surendhiran, K Chen, P Lv… - South African Journal of …, 2021 - Elsevier
The Astragalus propinquus is used in traditional Chinese medicines (TCM) for centuries.
However, its mechanism of action and functional targets remain elusive. The purpose of the …

Identification of genotypic variants and its proteomic mutations of Brazilian Sars-Cov-2 isolates

R Prathiviraj, P Chellapandi, A Begum, GS Kiran… - Virus research, 2022 - Elsevier
The second wave of COVID-19 caused by severe acute respiratory syndrome virus (SARS-
CoV-2) is rapidly spreading over the world. Mechanisms behind the flee from current …

[PDF][PDF] Reconstruction and analysis of the transcriptome regulatory network of Clostridium botulinum type a3 str. Loch maree

B Roja, L Thamanna… - Asian J Microbiol …, 2023 - envirobiotechjournals.com
Clostridium botulinum type A3 str. Loch Maree is a clinically important strain that produces
botulinum neurotoxin type A3 and causes foodborne, infant, and wound botulism worldwide …

Substrate-imprinted docking of Agrobacterium tumefaciens uronate dehydrogenase for increased substrate selectivity

A Murugan, R Prathiviraj, D Mothay… - International journal of …, 2019 - Elsevier
Agrobacterium tumefaciens uronate dehydrogenase (AtuUdh) belongs to the short-chain
dehydrogenase superfamily, specifically those acting on the CH-OH group of donor with …

Molecular Evolutionary Constraints that Determine the Avirulence State of Clostridium botulinum C2 Toxin

A Prisilla, R Prathiviraj, P Chellapandi - Journal of molecular evolution, 2017 - Springer
Clostridium botulinum (group-III) is an anaerobic bacterium producing C2 toxin along with
botulinum neurotoxins. C2 toxin is belonged to binary toxin A family in bacterial ADP …

Structural constraints-based evaluation of immunogenic avirulent toxins from Clostridium botulinum C2 and C3 toxins as subunit vaccines

A Prisilla, R Prathiviraj, R Sasikala… - Infection, Genetics and …, 2016 - Elsevier
Clostridium botulinum (group-III) is an anaerobic bacterium producing C2 and C3 toxins in
addition to botulinum neurotoxins in avian and mammalian cells. C2 and C3 toxins are …